Background: Directional migration requires removal of Rac1 from the back of the cell.Results: Coronin-1C and caveolin provide parallel pathways for constitutive recycling or fibronectin-inducible degradation of Rac1.Discussion: Redundant trafficking pathways facilitate polarity while migrating, and responsiveness to chemotactic gradients while stationary.Significance: Maintenance of polarized migration, when the chemotactic gradient has dissipated, is essential for wound healing over a period of days.
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