Iseia luxurians (M oric.) O 'D o n e ll, Isoquinolinone Alkaloids, ConvolvulaceaeA novel isoquinolinone alkaloid, iseluxine (1), has been isolated from the epigeal parts of Iseia luxurians (M oric.) O 'D o n e ll (C onvolvulaceae), a clim ber indige nous to the tropical A m ericas. Structural elucidation was achieved by H RM S, 'H N M R , 13C N M R , and H M B C spectroscopy. N-and / or O -m ethyl derivatives of 1 are already known from certain M agnoliidae families, e.g., the Fum ariaceae, the L auraceae, or the P apaveraceae. Iseluxine, the "missing link" in the biosynthesis o f these m ethyl derivatives from dopam ine, is the first isoquinoli none alkaloid characterized by a catechol substructure.
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