Background:The aim of this study was to analyze the first stages of progress in liver transplantation (LT) at a single center in Vietnam. Methods: This study analyzed data from patients and donors who participated in the LT program between August 2018 and December 2021 at University Medical Center, Ho Chi Minh City. Study measures included any difficulties encountered, as well as the post-LT outcomes for living donor LT (LDLT) and deceased donor LT (DDLT). The chi-square test and Kaplan Meier survival analysis were used to test the factors that influenced the outcomes. Results: A total of 18 adult recipients with LT (LDLT, n=16; DDLT, n=2) were included (mean age, 55.2±2.6 years; male, 88.9%). The most common post-LT complications were middle hepatic venous stenosis (20%) and graft rejection (22.2%). These complications were observed in LDLT patients. For DDLT, graft rejection (50%) was the only complication recorded. The survival rates for recipients at 3 months, 6 months, and 1 year were 100%, 88.9%, and 88.9%, respectively. The LDs had their right livers without the middle hepatic veins harvested, and biliary leakage (6.25%) was the only complication observed. There were no deaths among recipients or LDs during the operations or hospital stays. Conclusions: This study provides key details about the process of LT, and these positive outcomes support LT as an important therapy for end-stage liver disease and early hepatocellular carcinomas.

Highlights Non-motor features may negatively impact those with young-onset Parkinson disease. Sleep/fatigue was the most severely affected, followed by mood/cognition. These domains independently predicted health-related quality of life (HRQoL).

We investigated changes in some laboratory indices and the liver histology of chronic hepatitis patients who were exposed to dioxin. In 2014, we collected liver biopsy samples for histopathological examination from 33 chronic hepatitis patients living around the Da Nang Airbase, which is a dioxin-contaminated area due to the herbicide spraying in Vietnam. Dioxin exposure was measured by its levels in the blood. METAVIR classification was used to clarify the liver fibrosis stage. Laboratory tests included ten biochemical and six hematological indices that were measured in the blood. A regression linear model and binary logistic regression were used for data analysis. The observed alterations in the liver at the histological level mainly comprised hydropic degenerative hepatocytes, lymphocytes and polynuclear leukocytes surrounding the liver cells and granular and lipoic degeneration. In addition, increased TCDD levels were associated with increasing aminotransferase (AST), alanine aminotransferase, protein and total bilirubin levels and liver fibrosis stage. Similarly, increased TEQ-PCDD/Fs levels were associated with higher levels of AST and protein and liver fibrosis stage. In conclusion, dioxin exposure altered the liver histology and increased some biochemical marker indices and the liver fibrosis stage of chronic hepatitis patients living in dioxin-contaminated areas in Da Nang, Vietnam.

Evaluation of arsenic pollution in surface water and groundwarter layers in the Cát Tiên district of the Lam Dong province has been carried out during the period of 2013–2015. Arsenic concentrations of 37 samples of surface water and dug well water ranged from 0 to 5 ppb. 9/29 water samples drilling wells of the Quaternary groundwater layer had arsenic concentrations higher than those of the standard QCVN01:2009/BYT. The arsenic concentration of samples collected from the Cat Tien commune (CT-TT 04) and the Gia Vien commune (CT-GV 03) was about 10 times higher than that of the standard QCVN 01:2009/BYT. Especially, the arsenic concentration of the drilling well from Tu Nghia communes (CT-TN 04) was about 45 times higher than the standard QCVN 01:2009/BYT. Drilling wells with arsenic pollution had the Eh range from -1.4 mV to -186 mV. The concentrations of arsenic and ammonium of drilling wells in Gia Vien and Cat Tien commune were high. The concentrations of As3+and Fe2+ were higher than those of As5+ and Fe3+, respectively.

Introduction: Indocyanine green (ICG) clearance (through ICG retention rate at 15 minutes - ICG-R15) is proven to correlate with histological fibrosis stage. Child-Pugh score, although proven to have weaker correlation, is still one of pre-hepatectomy liver function assessments. This study is to compare ICG-R15 and Child-Pugh score in evaluation of histological fibrosis stage and predicting of post-hepatectomy liver failure (PHLF) and to create the model of staging estimation for fibrosis. Methods: A prospective cohort study was conducted in 340 patients of hepatectomy. ICG-R15, Child-Pugh score and platelet count (PLT) were analyzed to examine their association with histological fibrosis stage and PHLF. Ordinal logistic regression was used to establish the model of staging estimation for fibrosis. Results: Child-Pugh score showed no significant association with histological fibrosis stage (p = 0.257) while ICG-R15 had a weak correlation (r = 0.232, p < 0.001), INR had a weak correlation (r = 0.156, p = 0.004), PLT had a negative correlation (r = -0.378, p < 0.001). The histological fibrosis stage could be estimated based on gender, age, ICG-R15 and PLT with AUC of 0.68. ICG-R15 was shown to be related to PHLF (p = 0.039) in which non-PHLF group had 0.75 times lower ICG-R15 than PHLF group while Child-Pugh score was shown to be statistically insignificant. Conclusion: ICG clearance test was better than Child-Pugh score in evaluation of pre-hepatectomy liver function and predicting of PHLF. It was possible to estimate the histological fibrosis stage based on gender, age, ICG-R15 and PLT.