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the internet most commonly browse using a computer (62%), smartphone (28%), or tablet (10%). 46% of subjects use the internet daily. Subjects with diabetes were the most likely to monitor or keep track of their disease (69%), followed by COPD (49%), depression (46%), and OA (39%). Subjects with diabetes or OA were more likely than subjects with COPD or depression to use the internet to research their disease and/ or treatments and 47% of all subjects reported doing so on at least a monthly basis. Subjects across all cohorts were most likely to research information on their current treatments (77%) followed by impact of diet on disease (68%), new drugs (42%), and disease complications (41%). With respect to their general health, subjects across all cohorts were most likely to search online for food (72%) and exercise (52%) recommendations. ConClusions: The extent to which subjects with chronic disease use eClinical technology to track and research health information depends in part on which disease they have. Understanding the type of health information that patients investigate online may help identify areas for more effective intervention and use of eClinical technology. PIH46AlIgnIng PAtIent Centred evIdenCe generAtIon ACross tHe drug develoPment lIfeCyCle

A743reviewing how the use of a structured model for emotions can improve PRO instrument development by strengthening the role of emotions during CE. Methods: A literature review of CE with emotional motivations was undertaken to identify the most salient aspects for PRO instrument development. Results: The method for eliciting emotional motivations is based on motivation research and extraction techniques (see Forbes, 2010) containing, nine distinct categories of emotional motivation. The CE protocol relies upon neuroscience research (see Damasio 2010) which points to the power of a sub-800 millisecond response frame for eliciting purely emotional reactions to stimuli. Images validated in large sample research as uniquely evoking one of the nine motivational emotions are the stimuli for this emotional evocation procedure. This augmentation to typical CE has been used repeatedly to identify needs for emotional health among sufferers of diabetes, arthritis, and heart disease -in each case linking evocations to absence of needed emotional energies that could promote self-care and disease recovery. ConClusions: CE techniques for most PRO development do not allow investigators to sufficiently understand the patient experiences of physical symptoms, effect of ADLs, and the emotional consequences of a disease or condition of interest. Adding emotional motivation techniques to CEs will broaden our ability to capture the emotional experiences of patients so that related PRO instrument items may better represent the experiences of patients' suffering from various medical conditions.

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