In Europe, cases of chlamydia (CT), gonorrhoea (NG) and syphilis (TP) are rising and coinfections and reinfections are common. As there are limited data on factors associated with these events in Portugal, this study may be valuable to inform prevention strategies. We conducted an analytical cross-sectional study with all probable and confirmed cases of CT (including lymphogranuloma venereum), NG and TP notified in Portugal in the national system of epidemiological surveillance (SINAVE®) between January 1st, 2015 and December 31st, 2018. Descriptive and multivariable analyses were conducted and adjusted odds ratios (aORs) with 95% confidence intervals (CIs) were calculated. Among 6506 cases in SINAVE®, 858 (13.2%) were coinfections and 204 (3.1%) were reinfections. Coinfections were found in 14.0% of males and 10.2% of females, while reinfections were present in 3.8% of males and 0.8% of females. In multivariable analysis, coinfections were positively associated with being younger than 26 (aOR 2.45, 95% CI 1.81-3.30), living in Lisbon area (aOR 1.43, 95% CI 1.13-1.81), being symptomatic (aOR 1.82, 95% CI 1.53-2.18), being men who have sex with men (MSM) (aOR 1.63, 95% CI 1.28-2.07), HIV+ status (aOR 1.46, 95% CI 1.19-1.80) and being diagnosed in an NGO (aOR 1.68, 95% CI 1.29-2.19). Reinfections were positively associated with living in Lisbon area (aOR 2.53, 95% CI 1.43-4.47), being symptomatic (aOR 2.37, 95% CI 1.66-3.37), being MSM (aOR 3.69, 95% CI 2.17-6.30) and HIV+ status (aOR 1.68, 95% CI 1.18-2.39). This study contributes to identifying risk profiles for coinfection and reinfection by these STIs in Portugal. Younger age, living in Lisbon area, being MSM, HIV+ status and being diagnosed in an NGO are some of the associated factors. Targeted interventions are needed to tackle specific settings and populations to be successful in lowering STI's incidence in Portugal. Key messages We identified factors associated with coinfection and reinfection by chlamydia, gonorrhoea and syphilis in Portugal, that can be used to target interventions. A study to identify the changes and problems in sexual attitudes and sexual behaviour may be useful to help us understand this paradigm.
<b><i>Background:</i></b> Ovar was the first Portuguese municipality to declare active community transmission of SARS-CoV-2, with total lockdown decreed on March 17, 2020. This context provided conditions for a large-scale testing strategy, allowing a referral system considering other symptoms besides the ones that were part of the case definition (fever, cough, and dyspnea). This study aims to identify other symptoms associated with COVID-19 since it may clarify the pre-test probability of the occurrence of the disease. <b><i>Methods:</i></b> This case-control study uses primary care registers between March 29 and May 10, 2020 in Ovar municipality. Pre-test clinical and exposure-risk characteristics, reported by physicians, were collected through a form, and linked with their laboratory result. <b><i>Results:</i></b> The study population included a total of 919 patients, of whom 226 (24.6%) were COVID-19 cases and 693 were negative for SARS-CoV-2. Only 27.1% of the patients reporting contact with a confirmed or suspected case tested positive. In the multivariate analysis, statistical significance was obtained for headaches (OR 0.558), odynophagia (OR 0.273), anosmia (OR 2.360), and other symptoms (OR 2.157). The interaction of anosmia and odynophagia appeared as possibly relevant with a borderline statistically significant OR of 3.375. <b><i>Conclusion:</i></b> COVID-19 has a wide range of symptoms. Of the myriad described, the present study highlights anosmia itself and calls for additional studies on the interaction between anosmia and odynophagia. Headaches and odynophagia by themselves are not associated with an increased risk for the disease. These findings may help clinicians in deciding when to test, especially when other diseases with similar symptoms are more prevalent, namely in winter.
Chlamydia (CT), gonorrhoea (NG) and syphilis (TP) infections are rising and have an important burden in the EU/EEA. This study aims to describe the epidemiology of these infections in Portugal, between 2015 and 2018, in order to set a baseline for the recently created National Strategy for STI Control and to generate hypothesis on areas for improvement. We analysed data from the national system of epidemiological surveillance (SINAVE®) and described all probable and confirmed cases of CT, NG and TP notified in Portugal between January 1st, 2015 and December 31st, 2018.This reports the overall case evolution as well as specific characteristics of different groups. Throughout the analysed 4-year period there were 1267 cases of CT, 1917 of NG and 3240 of TP (probable and confirmed). Of CT cases, 70% (n = 891) occurred in males, 66.3% (n = 840) in people aged 18-35, 52.9% (n = 670) in heterosexuals and 42.9% (n = 543) in men who have sex with men (MSM). Of NG cases, 87.9% (n = 1686) were males, 90.8% (n = 1741) were <45 years-old and 51.2% (n = 982) were MSM. Of TP cases, 76.0% (n = 2462) were males, 64.8% (n = 2101) were <45 years-old, 41.1% (n = 1333) were heterosexuals and MSM accounted for 39.9% (n = 1294). The notified cases have doubled from 2015 to 2018 (1159 to 2354) and tripled in MSM (440 to 1312), with a 7.9, 4.1 and 1.6-fold increase in CT, NG and TP, respectively. For each infection, symptomatic cases contributed to 42.9% (CT), 14.6% (NG) and 81.9% (TP) of the overall. In similarity to European trends, CT, NG and TP infections seem to be rising in Portugal. Changes in patient behaviour, clinical practice, screenings, settings of diagnosis and notification should be further explored to better understand this trend, including clinical features. From our results, MSM and people aged <45 should be prioritised within the National Strategy for STI Control. A surveillance system evaluation could be considered for sensitivity and usefulness. Key messages The number of chlamydia, gonorrhoea and syphilis reported cases in Portugal raised in the four-year period between 2015 and 2018, with MSM accounting for 54.6% (1312/2403) of the cases in 2018. This sets up a baseline to guide the adoption of specific measures and the prioritisation of interventions. MSM should be given special attention when addressing new prevention strategies.
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