Red‐fleshed apples are preferred because of their high content of phenolics and antioxidants. In this study, the phenolic characteristics, antioxidant properties, and antihuman cancer cell properties of the four hybrids of Malus sieversii f. niedzwetzkyana (Ledeb.) M. Roem were analyzed. In addition, the antioxidant and anti‐proliferation properties of these apples were measured. Compared to “Fuji” apples, the red‐fleshed apples were rich in phenolic and flavonoid chemicals, ranging from 1.5‐ to 2.6‐fold and 1.4‐ to 2.4‐fold, respectively. In all antioxidant methods (DPPH radical‐scavenging capacity, ABTS radical scavenging activity, ferric reducing antioxidant power, and cell antioxidant capacity), “A38” obtained the highest antioxidant value, whereas “Fuji” got the lowest antioxidant value. The IC50 values ranged from 33.44 (“A38”) to 73.36 mg/mL (“Fuji”) for MCF‐7 and 20.94 (“A38”) to 39.39 mg/mL (“Fuji”) for MAD‐MB‐231. The red‐fleshed “A38” and “Meihong” exhibited higher antioxidant and antiproliferative activities in vitro because of the higher levels of phenolics, and the higher potential for development and utilization value. Practical Application The phenolic compounds, antioxidant activity, and antiproliferative activity in vitro of four red‐fleshed apple cultivars and one white‐fleshed apple cultivar were compared in this study. This information should assist to give a reasonable evaluation for scientists to breed new cultivars with high phenolics and to exploit the natural polyphenol.

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The aim of this study was to characterize the phenolic profiles in the extracts and digesta (after in vitro digestion) of different red‐fleshed apple fruit parts and to assess the effects of digestion on the in vitro antioxidant capacity and antiproliferative activity. The main polyphenols were identified by UPLC‐MS/MS and HPLC. Our results indicate that the digesta had less total phenolics, flavonoids, and anthocyanins, but more free phenolic acids, than the extracts. An analysis of the in vitro antioxidant capacity (including ABTS radical scavenging activity, DPPH radical‐scavenging capacity, ferric reducing antioxidant power [FRAP], and cellular antioxidant activity [CAA]) revealed that the digestion decreased the ABTS, DPPH, and FRAP values, but increased the CAA values, relative to the corresponding values for extracts. These results suggest that the digestion improved the effectiveness of the phenolic substances. Moreover, our findings imply that the digestion promoted the antiproliferative activity of red‐fleshed apple peels and flesh relative to the extracts. Future in vivo investigations are warranted based on the results of the current study. Practical Application The effects of an in vitro digestion on the phenolic compounds as well as the antioxidative and antiproliferative activities of red‐fleshed apple were evaluated. The resulting data may clarify the bioavailability of the polyphenols in red‐fleshed apple and enable scientists and consumers to exploit natural polyphenols.

In view of the difficulty of designing a high-order linear phase filter with prototype parameters directly, this paper proposes a new approach to rapidly construct a high order linear phase filter through cascading two same low-order linear phase filters. A twelve-order HTSC cascaded linear phase filter is fabricated on YBCO/LaAlO3/YBCO substrate with the dimension of 44.1mm ×31.4mm. The measured result shows that the filter has a 56 MHz passband at a center frequency of 1993 MHz. The minimum insertion loss in the passband is 0.59 dB. The group delay variation in passband is less than 5 ns over 78.5% of the filter bandwidth which is in good agree with the simulation result.