A new polyprenylated xanthone (¼ 9H-xanthen-9-one) and a new polyprenylated benzophenone, namely oblongifolixanthone A (1) and garciniagifolone A (2), were isolated from the bark of Garcinia oblongifolia, together with five known compounds including the four xanthones 3 -5 and 7 and a benzophenone 6. The structures of 1 and 2 were established by detailed analysis of their spectroscopic data, especially 1D-and 2D-NMR spectra and HR-ESI-MS data. All these compounds were assayed for their cytotoxic activities against three human tumor cell lines (HeLa, SGC7901, and HepG2). The 1,3,6,7-tetrahydroxy-9H-xanthen-9-one (3) was inactive, and the other compounds showed weak to moderate activity.

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