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A number of genetic studies have attempted to link interleukin-27 (IL-27) polymorphisms (rs153109, rs17855750 and rs181206) to the risk of cancer in Chinese population, including glioma, ovarian cancer, hepatocellular carcinoma, colorectal cancer, esophageal cancer, etc. However, the results were inconclusive. The aim of this study is to derive a more precise estimation of any association in a meta-analysis. We searched the PubMed database (up to 6 June 2014) for studies regarding the association of IL-27 polymorphisms (rs153109, rs17855750 and rs181206) and the risk of cancer in Chinese population. Odds ratios (ORs) together with their 95% confidence intervals (CIs) were calculated by using random/fixed effect model to assess the association. Sensitivity analyses were used to assess the stability of the results. Begg's test was performed to measure publication bias. A total of six eligible studies with 1684 patients and 1837 controls were included in this meta-analysis. IL-27 rs153109 polymorphism was significantly associated with cancer risk in Chinese population (GG versus AA: OR = 1.24, 95% CI = 1.00-1.54, p = 0.05). However, there were no associations between IL-27 rs17855750 and rs181206 polymorphisms and cancer risk in Chinese population. In conclusion, this meta-analysis indicated that IL-27 rs153109 polymorphism was associated with cancer risk in Chinese population.

Objectives: To explore the clinical effect and prognostic factors of mechanical thrombectomy in the treatment of acute ischemic stroke. Methods: The records of patients with acute ischemic stroke treated in our hospital from April 2020 to April 2021 were retrospectively selected. A total of 65 patients were treated with mechanical thrombectomy. After treatment, they were scored with modified Rankin Scale (MRS). The treatment effect and prognostic factors were analyzed. Results: The occluded vessels were successfully opened in 65 patients. The recanalization rate was 96.92%. There were no serious complications of thrombectomy. The time from femoral artery puncture to vascular recanalization was (84.06±16.64) minutes and the number of thrombectomies was (2.52±0.71). There were 42 patients with good prognosis and 23 patients with poor prognosis. Analysis of the prognostic factors showed that the time from onset to admission in the good prognosis group was shorter, the NIHSS score before thrombectomy was higher, and the Alberta stroke program early CT Score (ASPECT) score was lower as compared to the patients in the poor prognosis group. The grade of vascular recanalization in the good prognosis group was better than that in the poor prognosis group, and the level of PCT was lower (P<0.05). Logistic regression analysis showed that the time from onset to admission, NIHSS and ASPECT scores before thrombectomy were the prognostic factors of mechanical thrombectomy in the treatment of acute ischemic stroke. Conclusion: Mechanical thrombectomy is effective in the treatment of acute ischemic stroke and can effectively promote the recanalization of occluded vessels, but the NIHSS and ASPECT scores from the onset to the time of admission before thrombectomy can directly affect the prognosis of patients. doi: https://doi.org/10.12669/pjms.38.5.5723 How to cite this:Li L, Cheng P, Zhang J, Wang G, Hu T, Sun F. Clinical effect and prognostic factors of mechanical thrombectomy in the treatment of acute ischemic stroke. Pak J Med Sci. 2022;38(5):---------. doi: https://doi.org/10.12669/pjms.38.5.5723 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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