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Zusammenfassung Ziel Übersichtsarbeit zur Darstellung des Krankheitsbildes der Magendrehung beim Meerschweinchen. Material und Methoden Vier klinische Fälle einer Magendrehung beim Meerschweinchen wurden hinsichtlich des klinischen Bildes und der diagnostischen Möglichkeiten betrachtet. Es erfolgte eine Darstellung von Therapieversuchen und möglicher Alternativen. Potenzielle Risikofaktoren für die Erkrankung sowie deren Ätiologie und Pathophysiologie wurden diskutiert und mit den Verhältnissen bei anderen Tierarten verglichen. Ergebnisse Anhand der dargestellten Fälle wird deutlich, dass neben der Anamnese und klinischen Untersuchung die Röntgenuntersuchung das Mittel der Wahl zur Diagnose einer Magendrehung beim Meerschweinchen darstellt. In allen vier Fällen erfolgte nach der Diagnose ein chirurgischer Therapieversuch. Ein Tier wurde intraoperativ euthanasiert, drei Patienten verstarben nach der Operation. Schlussfolgerung und klinische Relevanz Die Magendrehung beim Meerschweinchen ist als absoluter Notfall einzustufen. Neben der sofortigen Stabilisierung des Patienten bedarf es fast immer einer chirurgischen Intervention. Die Prognose der Erkrankung ist als vorsichtig bis schlecht einzustufen.

An 8-month-old, male African hedgehog clinically displayed a wobbly walk, anuria, inappetence and apathy, whereupon the suspected diagnosis wobbly hedgehog syndrome was made. After exacerbation, the hedgehog was euthanized. Histologically, a tumour mainly consisting of medium-sized, oval tumour cells and a smaller number of spindeloid cells was found in the cerebrum. The tumour contained neuropil islets and extracellular myxoid material. Immunohistochemically, the tumour cells expressed oligodendroglial (neurite outgrowth inhibitor, Nogo-A; oligodendrocyte transcription factor, Olig-2) and neuronal (neuron-specific enolase, NSE; microtubule-associated protein-2a, MAP-2a; synaptophysin) cell markers. Based on these findings, an oligodendroglioma with neuronal differentiation was diagnosed. Such a brain tumour has to date not been reported for African hedgehogs. At necropsy, a severely filled and dilated urinary bladder was observed, which was presumably caused by a central blockade of the micturition centre in the brain. In the case of neurological symptoms in young hedgehogs, a primary brain tumour should, as in adults, be considered as a differential diagnosis. As further differentials, inflammatory-infectious (rabies, herpes, baylisascariosis), degenerative (cardiomyopathy, intervertebral-disc disease), traumatic, alimentary (vitamin-B deficiency) and metabolic-toxic (heat-cold-torpor, hepatic encephalopathy) triggers have to be considered.

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A high prevalence of AA-amyloidosis was identified in a breeding colony of northern tree shrews ( Tupaia belangeri) in a retrospective analysis, with amyloid deposits in different organs being found in 26/36 individuals (72%). Amyloid deposits, confirmed by Congo red staining, were detected in kidneys, intestines, skin, and lymph nodes, characteristic of systemic amyloidosis. Immunohistochemically, the deposited amyloid was intensely positive with anti-AA-antibody (clone mc4), suggesting AA-amyloidosis. The kidneys were predominantly affected (80%), where amyloid deposits ranged from mild to severe and was predominantly located in the renal medulla. In addition, many kidneys contained numerous cysts with atrophy of the renal parenchyma. There was no significant association between concurrent neoplastic or inflammatory processes and amyloidosis. The lack of distinctive predisposing factors suggests a general susceptibility of captive T. belangeri to develop amyloidosis. Clinical and laboratory findings of a female individual with pronounced kidney alterations were indicative of renal failure. The observed tissue tropism with pronounced kidney alterations, corresponding renal dysfunction, and an overall high prevalence suggests amyloidosis as an important disease in captive tree shrews.