An In(OTf) 3 -catalyzed domino reaction involving sequential oxidative ring opening of aziridines by using the solvent dimethyl sulfoxide and intramolecular Michael addition has been developed for the modular synthesis of 2-aminoindanone compounds by the formation of one new CO bond and one new C−C bond. The notable feature of this strategy includes broad substrate scope, excellent trans-diastereoselectivities, highly functionalized products, and mild conditions. The catalyst In(OTf) 3 plays an important role in the formation of the indanone ring.

A [Cp*RhCl2]2‐catalyzed formal [3+3]‐cycloaddition involving sequential ring opening of aziridines initiated by C−H activation and Michael addition has been developed for the construction of cis‐1,4‐disubstitued tetrahydro‐γ‐carbolines. The advantages of this strategy include broad substrate scope, excellent cis‐diastereoselectivities, highly functionalized products, and mild conditions.

A stepwise cyclization involving sequential ring opening of aziridines and Pictet-Spengler reaction has been developed for the synthesis of 4-spiroannulated tetrahydroisoquinoline compounds (22 examples). The novel features of this strategy...