Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS-CoV-2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre-operative SARS-CoV-2 infection were compared with those without previous SARS-CoV-2 infection. The primary outcome measure was 30-day postoperative mortality. Logistic regression models were used to calculate adjusted 30-day mortality rates stratified by time from diagnosis of SARS-CoV-2 infection to surgery. Among 140,231 patients (116 countries), 3127 patients (2.2%) had a pre-operative SARS-CoV-2 diagnosis. Adjusted 30-day mortality in patients without SARS-CoV-2 infection was 1.5% (95%CI 1.4-1.5). In patients with a pre-operative SARS-CoV-2 diagnosis, mortality was increased in patients having surgery within 0-2 weeks, 3-4 weeks and 5-6 weeks of the diagnosis (odds ratio (95%CI) 4.1 (3.3-4.8), 3.9 (2.6-5.1) and 3.6 (2.0-5.2), respectively). Surgery performed ≥ 7 weeks after SARS-CoV-2 diagnosis was associated with a similar mortality risk to baseline (odds ratio (95%CI) 1.5 (0.9-2.1)). After a ≥ 7 week delay in undertaking surgery following SARS-CoV-2 infection, patients with ongoing symptoms had a higher mortality than patients whose symptoms had resolved or who had been asymptomatic (6.0% (95%CI 3.2-8.7) vs. 2.4% (95%CI 1.4-3.4) vs. 1.3% (95%CI 0.6-2.0), respectively). Where possible, surgery should be delayed for at least 7 weeks following SARS-CoV-2 infection. Patients with ongoing symptoms ≥ 7 weeks from diagnosis may benefit from further delay.

SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS-CoV-2 diagnosis was defined as peri-operative (7 days before to 30 days after surgery); recent (1-6 weeks before surgery); previous (≥7 weeks before surgery); or none. Information on prophylaxis regimens or pre-operative anti-coagulation for baseline comorbidities was not available. Postoperative venous thromboembolism rate was 0.5% (666/123,591) in patients without SARS-CoV-2; 2.2% (50/2317) in patients with peri-operative SARS-CoV-2; 1.6% (15/953) in patients with recent SARS-CoV-2; and 1.0% (11/1148) in patients with previous SARS-CoV-2. After adjustment for confounding factors, patients with peri-operative (adjusted odds ratio 1.5 (95%CI 1.1-2.0)) and recent SARS-CoV-2 (1.9 (95%CI 1.2-3.3)) remained at higher risk of venous thromboembolism, with a borderline finding in previous SARS-CoV-2 (1.7 (95%CI 0.9-3.0)). Overall, venous thromboembolism was independently associated with 30-day mortality ). In patients with SARS-CoV-2, mortality without venous thromboembolism was 7.4% (319/4342) and with venous thromboembolism was 40.8% (31/76). Patients undergoing surgery with peri-operative or recent SARS-CoV-2 appear to be at increased risk of postoperative venous thromboembolism compared with patients with no history of SARS-CoV-2 infection. Optimal venous thromboembolism prophylaxis and treatment are unknown in this cohort of patients, and these data should be interpreted accordingly.

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Introduction: Obstructive Syndrom Apnea (OSA) has a worldwide incidence of 0.3 to 5%, predominantly in men. This pathology causes an obstruction of the upper airway with a significant risk of asphyxia and sudden death. The objective of our study was to report the case of a patient with OSA treated in Dento-Facial Orthopedics. Observation: This was a 41-year-old man with risk factors for OSA, dento-arch dysmorphosis, and maxillo-mandibular bone deformity. The nasofibroscopy revealed a narrowed oropharynx, an airway obstruction in the supine position. The polysomnography concluded to the diagnosis of OSA in its severe form with 45 apneas in one night, an oxygen saturation of 85%. The treatment consisted of a mandibular advancement prosthesis. Discussion: OSA is a serious pathology under-diagnosed in Madagascar. Repeated apneas and hypopneas are associated with significant decreases in oxygen partial pressure. The most reliable and widely used test in the world is polysomnography. Treatment of OSA with positive pressure allows the increase of the pressure inside the pharynx. Mandibular advancement prostheses allow for promandibulia. These therapeutic devices improve the quality of life of our patient. By traction system, the device allows a mandibular protrusion during sleep. Conclusion: The treatment of OSA consists of a multidisciplinary management including Dento-Facial Orthopedics and dental prosthesis.

Background: The acute mediastinitis also called Descending Necrotizing Mediastinitis or Cervico-mediastinitis necrotizing fasciitis is a disease which is the result of a spread of severe cervical infection down to the mediastinum. Method: A retrospective study was done at the surgical intensive care unit of Joseph Ravoahangy Andrianavalona's hospital about the management of descending necrotizing mediastinitis from 1 st January 2009 to 31 st December 2012. Result: Fourteen cases were reported during four years. The mean age of the patients was 30 years and 8 months, the sex ratio was 1.33. The most common cause found in every cases were severe cervical infections such as fasciitis by dental origin, peritonsillar abcess, sore throat, combined with the administration of non steroid antiinflammatory, of corticoid, of inappropriate antibiotic and also the patients' health status. The suspicion of diagnosis is made clinically with chest pain associated with dyspnea, fever or septic shock and confirmed by radiologic findings. Conclusion: Nowadays, the mortality rates is high about 71, 42% for our cases. Collaboration of the thoracic surgeons and anesthetists is recommended for an early trancervical drainage of the mediastinitis. In Madagascar, the fasciitis by odontogenic infection is the most common cause of mediastinitis due to the lack of dental care.