Ruta graveolens, locally called sodab or sadab, is a known medicinal plant in north of Iran. The plant is a source for the production of secondary metabolites such as Glycosides, lignins, alkaloids, Coumarins, flavonoids and phenolic acids. In this work, the effect of salicylic acid on phenols and flavonoids contents of R. graveolens were investigated in the cell suspension culture. A significant enhancement in total phenolic and flavonoids contents were observed in salicylic acid treated samples. The results revealed that salicylic acid (10 mg/ml) showed as maximum as 3.14 fold enhancement in total flavonoid content (40.35 mg/g) and salicylic acid (20 mg quercetin equivalent/g of extract powder) showed as maximum as 18.33 fold improvement in total phenolic content (438.75 mg gallic acid equivalent/g of extract powder). Also in this study, salicylic acid (10 mg/ml) showed as maximum as 3.55 fold increase in DPPH radical-scavenging activity compared to control. These results suggest that the positive effect of salicylic acid on phenols and flavonoids content and DPPH scavenging activity in cell suspension culture. This effect was dose dependent.

Objective: Schizophrenia is an acute mental disorder with unde ned etiology. The high heritability of the disease hints that several genetic variants and polymorphisms contribute to schizophrenia symptoms and severity. Former molecular evidence shed a light on the association of serotonergic pathway genetic polymorphisms with schizophrenia. Here, we investigated the association between schizophrenia and two SNPs from one haplotype block, which lies within 5-hydroxytryptamine receptor 2A(5-HTR2A) in the Iranian population.Material and methods: Blood samples were collected from one-hundred and fty-two patients diagnosed with schizophrenia and one-hundred and fty-eight age and sex matched healthy control. Participants were genotyped for rs6311 and rs6313 using PCR-RFLP. R programming language and Haploview software respectively were leveraged for statistical and haplotype inference.Results: The results signi ed that there was no signi cant association between rs6313 and schizophrenia. However, rs6311 T allele independently and in a rs6311-rs6313 haplotype signi cantly associated with schizophrenia. Also, the general linear model con rmed the potential predictor role of rs6311 for schizophrenia. Moreover, the C allele of rs6313 demonstrated more frequency among females compared to males.Conclusion: This study elucidated the association of rs6311 and rs6311-rs6313 haplotype with schizophrenia in the Iranian population and also suggested a potential schizophrenia risk predictor role for rs6311.