No abstract

This paper describes a full vector intensity probe which advances the field of sound intensity and sound source direction estimation using six matched rotating and variable directional microphones. The probe has three pairs of microphones at an equal spacing of 30 mm that are set up in each of the x, y, and z directions and share the same observation point. The calibration method using the rotating microphone system is effective to correct position errors in the y- and z-axes microphone pairs. Sound intensity measurements using the variable directional microphone method can locate with accuracy a sound source, i.e., the structure parts radiating most acoustic energy. The system can find the maximum sound intensity level and beamwidth of the major lobe, and the peak sound intensity levels of the minor lobes. Therefore, a procedure for sound power determination based on minimum measurement data is theoretically and experimentally discussed. Consequently, it is possible to reconstruct only parts of the system emitting the most noise and measure efficiently the sound power level.

Intelligent neurosurgical instruments are feasible and suitable for on-going evaluation in practical tasks, including in-vivo animal testing.

Fas/APO-1 and TNF receptor 1 share a common signaling motif in their cytoplasmic tail called the "death domain." Using the death domain as bait in the yeast two-hybrid system, several death domain-containing proteins that participate in cell death signaling have been identified. Here we report the isolation of a novel protein, sentrin, which interacts with Fas/APO-1 and TNF receptor 1 but not with FADD/MORT1 or CD40. Two-hybrid interaction assays reveal that sentrin associates only with the signal-competent forms of Fas/APO-1 or TNF receptor 1 death domains. Sentrin is a novel protein of 101 amino acids with homology to ubiquitin, Nedd8, and a Saccharomyces cerevisiae protein, Smt3. When overexpressed, sentrin provides protection against both anti-Fas/APO-1 and TNF-induced cell death.

BACKGROUND: Although it is useful for COPD patients to relieve their dyspnea by bracing their arms, the relationships between the arm bracing posture and expiratory flow limitation (EFL) and lung volume are unknown. Whether arm bracing affects dyspnea, EFL, and lung volume in elderly COPD patients was investigated. METHODS: Sixteen elderly subjects (median [interquartile range] age 81 [77-85] y) with stable COPD (percent-of-predicted FEV 1 50.9 [31.3-64.9] %) and 16 agematched healthy subjects were studied. Breathing patterns, EFL, lung volume, S pO 2 , and heart rate during quiet breathing were randomly evaluated in 3 standing postures: erect, leaning forward, and arm bracing. Dyspnea was also assessed for each posture with a Borg dyspnea score at the end of the test. RESULTS: Lung volume was significantly higher with arm bracing than with the other postures in both groups (P < .05). Breathing patterns, S pO 2 , and pulse rate were not significantly different among the 3 postures in both groups. However, EFL and Borg dyspnea scores were significantly lower with arm bracing than with the other postures in COPD subjects (P < .01). CONCLUSIONS: The decreased EFL in the arm bracing position may be caused by breathing at a higher lung volume than in the erect position, which may be one of the factors relieving dyspnea in elderly COPD patients.