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Two natural products, synerazol and pseurotin E, were synthesized from the natural product pseurotin A in 58% and 57% yields, respectively in one-pot procedures. This work also establishes the absolute stereochemistry of pseurotin E. , and apomorphineantagonistic activity [5]. Pseurotin A (1) possesses a highly substituted 1-oxa-7-azaspiro[4,4]non-2-ene-4,6-dione skeleton. The structure and absolute stereochemistry of 1 have been determined by a single-crystal X-ray analysis of its 12,13-dibromo derivative [6]. The core structure of 1 is found in other natural products, too (Fig. 1). These pseurotin-related natural products also possess interesting biological activities, including apomorphine-antagonistic activity in the cases of pseurotin D [5]

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