Objetive: This study aims to compare the curative effect of ultrasound guided foam sclerotherapy in combination with ligation of great saphenous varicose vein with stripping of great saphenous vein in the treatment of great saphenous varicose veins.Methods: 103 cases of patients with great saphenous varicose veins were randomly divided into two groups, group A 54 cases underwent high ligation of great saphenous vein and stripping of the saphenous vein, group B 49 cases performed high ligation of great saphenous vein combined with foam slcerotherapy, and the operation time, postoperative recovery time, the duration of pain, cost of surgery, incidence of complications, quality of life, and the recurrence rate were compared. Results:The operation time, postoperative activity recovery time and duration of pain of group B was lower than that of group A (P < 0.05). There was no obvious difference of surgery expenditure between the two groups (P = 0.246). At three months after operation, life quality evaluation was statistically significant different between two groups of patients (P < 0.01) according to the aberdeen varicose vein questionnaire (AVVQ). At six months after operation, the cure rate of group B was 87.8%, and the cure rate of group A was 92.6%. Conclusions:Compared with stripping of great saphenous vein, ultrasound guided foam sclerotherapy in combination with great saphenous vein ligation can shorten operation time, and decrease the postoperative discomfort, but which has lower curative rate than the latter.