No abstract

The inhibitory effects against a human immunodeficiency virus (HIV) in vitro and the structural studies on curdlan sulfate were investigated. Curdlan, a natural linear (l-*-3)-/8-D-glucan, was sulfated by piperidine-N-sulfonic acid in dimethyl sulfoxide to give curdlan sulfates with several molecular sizes and different sulfur contents. Curdlan sulfate with a sulfur content of 14.4% completely inhibited the infection of HIV in the drug concentration of as low as 3.3 pg/mh. This is one of the most potent anti-AIDS viral polysaccharides. The high-resolution NMR analysis including COSY and RELAYED-COSY experiments revealed that for a polymer with the number of sulfate groups per glucose unit (DS) of 1.6 the sulfate group was introduced to C6, C4, and C2 positions of the glucose unit, respectively.

No abstract

No abstract

No abstract