No abstract

The therapeutic potency of intraperitoneally administered methocarbamol was examined against acute oral intoxication of rats caused by lethal doses of pyrethroids (fenvalerate, cypermethrin, fenpropathrin and permethrin). Methocarbamol was initially administered a dose of 400mg/kg (body weight), followed by repeated doses of 200mg/kg, when tremors or hyperexcitability to sound was observed. Methocarbamol markedly decreased the mortality; 80% mortality caused by an administration of 850mg/kg (body weight) fenvalerate to 0%, 80% mortality by 850mg/kg cypermethrin to 0%, 60% mortality by 100mg/kg fenpropathrin to 0% and 70% mortality by 850mg/kg permethrin to 10%, and it was effective in alleviating motor symptoms such as fibrillation, tremors, hyperexcitability, clonic seizures and/or choreoathetotic movements. A subcutaneous administration of 25mg/kg (body weight) atropine sulfate was also effective in mitigating salivation produced by fenvalerate and cypermethrin.