Chondroid syringomas are rare, benign adnexal tumor of the skin arising from the eccrine and apocrine sweat gland with tumor differentiation in the epithelial and mesenchymal tissues. In 1859, Billroth first described chondroid syringomas as a mixed tumor of the skin due to its resemblance to the benign mixed tumor arising from salivary gland. [1,2] They most commonly occur in the head and neck, although they may be also found in the limbs, trunk, axilla, genitalia. The reported incidence is <0.01% of all primary skin tumors. An 80-year-old male patient presented to the surgery clinic with a chief complaint of painless, slow-growing swelling on his right mandible, which gradually developed over the period of 20-25yrs. A single, mobile, firm, nontender, nodular surface with subcutaneous plane mass was located on his mandible, which was 6.5cm in diameter. The mass was surgically excised and sent for the histopathological evaluation. The results of biopsy confirmed the diagnosis of chondroid syringoma and showed no evidence of malignancy. In this article, we present a case of giant chondroid syringoma over right mandible in the light of literature review.