Purpose The purpose of this paper is to examine meaning in life as an important resource during the COVID-19 pandemic. Design/methodology/approach This paper summarized key research establishing links between meaning in life and mental health and well-being variables, reviewed the literature on meaning as a protective factor and meaning-making as a coping mechanism amidst the COVID-19 pandemic, as well as provided focal points in cultivating meaning in life. Findings Studies strongly support the notion that meaning in life is essential for health and well-being. Research also suggests that meaning protects against worsening mental health, and that engaging in meaning-making is a coping process that ultimately leads to improved adjustment despite the stressors of the COVID-19 pandemic. Eight themes are also identified in cultivating skills to build meaning during adverse times. Practical implications Integrating what research has found about meaning, resilience and coping can help individuals develop practical strategies to cultivate meaning in their lives to support themselves and their communities during stressful times. Originality/value Understanding the ways in which meaning can support individuals’ health and well-being is critical during a global upheaval such as that of the COVID-19 pandemic.