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Obesity is one of the main preventable risk factors in post-menopausal breast cancer. This retrospective cross-sectional study aimed to demonstrate the clinical and epidemiological profile of breast cancer patients diagnosed in the period from 2013 to 2018 in the North of Mato Grosso, Brazil and to verify the prevalence and influence of overweight and obesity in these patients. Data were collected from patient’s medical records who were diagnosed with breast carcinoma in the Department of Oncology of Santo Antônio’s Hospital, in Sinop-MT. 196 patients were included. 99.5% were women. The majority were married, ≥50 years old (57.7%) and overweight or obese. In the overweight and obesity group the percentage of patients with invasive breast carcinoma were significantly higher when compared with eutrophic group (p=0.03). In all groups the profile of estrogen and progesterone receptors positive and HER-2 negative were more prevalent, however, the frequency of triple negative profile was higher in the overweight (7.1%) and obesity (6.3%) group when compared with control (4.3%) group, as well as the presence of hypertension and diabetes. In conclusion, it was observed a high prevalence of overweight and obesity in breast cancer patients, which contributed to modify the histological type of breast cancer (high prevalence of invasive and lobular carcinomas), increase the frequency of patients in stages 3 and 4, the percentage of triple negative profile and the frequency of other comorbidities, as hypertension and diabetes. Furthermore, metformin, an antidiabetic drug, seems to be contributing to reduce tumor development and improve the clinical profile and prognosis in diabetic breast cancer patients.

Breast cancer is a multifactorial disease that have been increasing in an alarm rate worldwide, and has overweight and obesity as important risk factors, being considered a significant public health problem. The present study aimed to demonstrate the clinical and epidemiological profile of breast cancer patients diagnosed in Sinop-MT (Brazil) and analyze the prevalence of overweight and obesity in these patients. This is a descriptive study, with data collected by analysis of patient’s medical records who were diagnosed with breast carcinoma in the Department of Oncology of Santo Antônio’s Hospital. Data were tabulated and analyzed in an Excel® spreadsheet software (Office 365), with a descriptive analysis in percentage. Results demonstrated that 100% of patients were women; 85.7% were affected by ductal and/or lobular breast carcinomas; all deaths occurred in patients over 40 years and 75% of deaths occurred in advanced stages; being 68.75% of the most severe cases’ stages present in the oldest patients. Furthermore, it was observed that 37.12% of the patients were classified as overweight or obese, 88.57% were treated with chemotherapy and 91.44% treated with combined therapies. In conclusion, it was observed that a great number of breast cancer patients were overweight/obese, presented ductal and lobular carcinoma, the deaths occurred predominantly in the over forty years and were related with the presence of metastasis and advanced stage.