Wearable biosensors for real-time and non-invasive detection of biomarkers are of importance in early diagnosis and treatment of diseases. Herein, a high-performance wearable biosensing platform was proposed by combining a three-dimensional hierarchical porous Au hydrogel-enzyme electrode with high biocompatibility, activity, and flexibility and soft-MEMS technologies with high precision and capability of mass production. Using glucose oxidase as the model enzyme, the glucose sensor exhibits a sensitivity of 10.51 μA mM −1 cm −2 , a long durability over 15 days, and a good selectivity. Under the mechanical deformation (0 to 90°), it is able to maintain an almost constant performance with a low deviation of <1.84%. With the assistance of a wireless or a Bluetooth module, this wearable sensing platform achieves realtime and non-invasive glucose monitoring on human skins. Similarly, continuous lactic acid monitoring was also realized with lactate oxidase immobilized on the same sensing platform, further verifying the universality of this sensing platform. Therefore, our work holds promise to provide a universal, high-performance wearable biosensing platform for various biomarkers in sweat and reliable diagnostic information for health management.

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A novel biodegradable magnetic-sensitive shape memory poly(E-caprolactone) nanocomposites, which were crosslinked with functionalized Fe 3 O 4 magnetic nanoparticles (MNPs), were synthesized via in situ polymerization method. Fe 3 O 4 MNPs pretreated with g-(methacryloyloxy) propyl trimethoxy silane (KH570) were used as crosslinking agents. Because of the crosslinking of functionalized Fe 3 O 4 MNPs with poly(E-caprolactone) prepolymer, the properties of the nanocomposites with different content of functionalized Fe 3 O 4 MNPs, especially the mechanical properties, were significantly improved. The nanocomposites also showed excellent shape memory properties in both 60 8C hot water and alternating magnetic field (f 5 60, 90 kHz, H 5 38.7, 59.8 kA m 21 ).In hot water bath, all the samples had shape recovery rate (R r ) higher than 98% and shape fixed rate (R f ) nearly 100%. In alternating magnetic field, the R r of composites was over 85% with the highest at 95.3%. In addition, the nanocomposites also have good biodegradability.

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A simple and rapid simultaneous sensing strategy of multiple biomarkers is of great importance but challenging in health diagnosis. In this study, a novel free-standing edge-rich graphene film (fs-ERG) was...