Objectives: Hashimoto's thyroiditis (HT) is the most common cause of hypothyroidism. The exact mechanism initiating the development of HT is not yet clear. This study aimed to investigate the correlation between HT and the presence of Epstein-Barr virus (EBV) in a Sudanese population. Results: EBV-LMP1 was detected in 11.1% of HT cases, which is consistent with previous studies. Studies have reported a wide range of frequencies indicating the presence of EBV in HT, and patients with autoimmune thyroiditis have increased titers of anti-EBV antibodies in their sera compared to healthy subjects. Intrathyroidal EBV-infected B cells may be responsible for the increased risk of development of B-cell lymphoma in the thyroid gland in patients with autoimmune thyroiditis. Our study suggests that regular follow-up is necessary for patients diagnosed with HT and are positive for EBV, as antiviral therapy is not applicable due to the risk of thyroid dysfunction. The study suggests an association between EBV and HT, but causation cannot be determined. The study also highlights the need for further research to determine the viral role and correlate it with the severity and progression of HT.

Background Intracranial hemorrhage is the third most frequent cause of cerebrovascular disease, also known as cerebral bleed, intraparenchymal bleed and hemorrhagic stroke. This study was designed to detect the possible present of factor II   polymorphism (G20210A) among Sudanese patients with Intercereberal hemorrhage. Material and method This study was cross sectional hospital-based study,conducted at the research laboratory of the national center of neurological sciences (NCNS), Khartoum, Sudan during the period June 2022 to August 2022.It included all patients attended with intracerebral hemorrhage, demographic data ( age , gender, associated disease ). DNA extraction was done from blood of all patients and control.PCR for factor prothrombin gene was done and thus Sanger sequencing. Results: The PCR results showed; 100% positive forfactor II gene. And sequencing result showed base bare exchange in factor II gene G to A (G20210A)polymorphism . Conclusion Factor II gene polymorphism (G20210A) was detected and might be association with Intercereberal hemorrhage among Sudanese patients

Background: Intracerebral hemorrhage (ICH) is a sudden bleeding into the tissues of the brain, into its ventricles, or into both. It is the second most common subtype of stroke and is a critical disease usually leading to severe disability or death. Material and method: This study was a cross sectional hospital-based study, conducted at the research laboratory of the national center of neurological sciences (NCNS), Khartoum, Sudan during the period June 2022 to August 2022.It included all patients attended with intracerebral hemorrhage. DNA extraction was done from blood of all patients and control. PCR for factor XIII gene was carried out and thus Sanger sequencing to both cases and controls. Results: The PCR results showed; 100% samples were positive for factor XIII gene.Sequencing result showed the detection of threepolymorphisms in factor XIII gene (G>T, A>G and C>T) . Conclusion: The detected factor XIII gene polymorphisms (G>T, A>G and C>T) might be associated with intercereberal hemorrhage among Sudanese patients. Keywords: Factor XIII, gene, polymorphism, hemorrhage, stroke, cerebrovascular

Background Intracranial hemorrhage refers to any bleeding within the intracranial vault, including the brain parenchyma and surrounding meningeal spaces. In Sudan, there is no published data regarding factor V Leiden mutation. Therefore this study was designed to detect the possible present of factor V polymorphism (G1691A) among Sudanese patients with intercereberal hemorrhage. Material and method This study was a cross sectional hospital-based study, conducted at the research laboratory of the national center of neurological sciences (NCNS), Khartoum, Sudan during the period June 2022 to August 2022.It included all patients attended with Intracerebral hemorrhage, DNA extraction was done from blood of all patients and controls.PCR for factor V gene was done and thus Sanger sequencing. Results The PCR results showed; 100% were positive for factor V gene. Sequencing results revealed single based exchange in factor V geneG to A (G1691A). Conclusion Factor V gene polymorphism (G1691A) was detected and might be in association with intercereberal hemorrhage among Sudanese patients

No abstract