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BackgroundOsteoarthritis-induced pain is a result of nociceptor stimulation, associated with local tissue damage and inflammation. Resent data suggest the presence of neuropathic pain symptoms in patients with osteoarthritis.ObjectivesThe aim of this study was to estimate the structure of pain syndrome, reveal the presence of neuropathic pain (NP) component, symptoms and signs of NP in patients suffering from knee osteoarthritis.MethodsWe've examined 44 patients with knee osteoarthritis of the II-III stages by the Kallgrene-Lawrence scale aged 47–85 years (average age 66,1±1,5 years). Patients were divided according to age into next groups: 47–60, 61–74, 75–85 years. To assess the NP component, we used screening scales painDETECT, LANSS, DN4 questionnaires. To assess intensity of pain, visual analogue scale (VAS) was used. Besides WOMAC and EuroQol-5D questionnaire were applied. For statistical analysis of results, ANOVA, correlation and regression analysis, chi square (χ2) were applied.Results72,7% of patients with knee osteoarthritis examined by painDETECT were unlikely to have the NP component, 22,7% might possibly, 4,6% – probably. LANSS scale: 25% were probably to have NP. DN4 scale: 31,2% probably had NP. Moderate to significant correlations were found between intensity of pain by VAS data and Neuropathic Pain Scales (painDETECT, LANSS, DN4) data (p<0,05). It was established than higher results of screening by painDETECT and DN4 positively correlate with a disturbance of physical function tested by WOMAC (p<0,05). PainDETECT data have moderate to significant correlations with EuroQol-5D questionnaire (p<0,01). Verbal descriptors as pins and needles, tingling, numbness and allodynia, pain from light touch which are revealed by 3 screening scales can significantly contribute to the likely neuropathic component in patients with knee osteoarthritis (p<0,05). Burning pain (p<0,01), pins and needles (p<0,05) can be associated with a more severe pain in patients with knee osteoarthritis.ConclusionsThus, in patients with osteoarthritis the pain syndrome may reveal NP features. Identification of these would promote a targeted treatment strategy.Disclosure of InterestNone declared

BackgroundNeuropathic pain caused by the musculoskeletal diseases has recently been the focus of numerous studies.ObjectivesThe aim of this study was to estimate the structure of pain syndrome and reveal the presence of neuropathic pain component in patients suffering from the musculoskeletal diseases.MethodsWe've examined 68 patients aged 45-85 years (average age 67,6±1,3years). Patients were divided into 3 groups: A – patients with osteoporosis and vertebral fractures (N=29), B – patients with low back pain (N=22), C – patients with osteoarthritis of knee joints (N=17). To assess the NP component we used painDETECT, LANSS, DN4 questionnaires.ResultsRegression analysis shows correlation between the questionnaires: LANSS and painDETECT (r=0.73, p=0.000001), DN4 and painDETECT (r=0.73, p=0.000001). 63,6% of patients with osteoporosis examined by painDETECT were unlikely to have the NP component, 17,2% might possibly, 17,2% – probably. LANSS scale: 24,1% were probably to have NP. DN4 scale: 37,9% probably had NP. 63,7% of patients with low back pain examined by painDETECT were unlikely to have NP, 22,7% might possibly, 13,6% – probably. LANSS scale: 22,7% were probably to have NP. DN4 scale: 36,4% had probably NP. 64,7% of patients with osteoarthritis of knee joints examined by painDETECT were unlikely to have the NP component, 29,4% might possibly, 5,9% - probably. LANSS scale: 23,5% probably had NP. DN4 scale: 41,2% had probably NP.ConclusionsThus, in patients with musculoskeletal diseases the pain syndrome may include NP features. Identification of these would promote a treatment strategy targeted at the NP.Disclosure of InterestNone declared

Purpose: Evidences show that obesity is a great risk factor in the development of knee osteoarthritis (OA). In addition, they also demonstrate that individuals with higher body mass index (BMI) have greater pain and more severe OA. However, the association between the different categories of BMI and functional activities, such as ascending and descending stairs, remains unclear. Therefore, the aim of this study was to evaluate and to compare the results obtained in the Stair Climbing Test, as well as the items corresponding to this functional activity in WOMAC questionnaire in individuals with knee OA (OAG) and healthy (CG), categorized by BMI (normal, overweight and obese). Methods: Patients with knee OA were selected based on the American College of Rheumatology criteria (ACR) and classified by the Kellgren and Lawrence scale. One hundred and sixteen participants (82 with knee OA and 34 healthy), with a mean age of 53.44 ± 8.151 years (OAG); 55.90 ± 7.135 (CG) years, were classified by body mass index (BMI) among normal: 18.5e24.9; overweight: 25.0e29.9 and obese 30 kg/ m 2. All participants answered the WOMAC (Western Ontario and McMaster Universities), a self-applied questionnaire. For the present study, it was considered the final score of the activities "ascending stairs" and "descending stairs" from the "physical function" of WOMAC domain; thus, the amounts were considered worse as higher the score achieved. In addition, the participants performed the Stair Climbing Test. The test should be performed as quickly as possible by the patients, and the total test time was timed in seconds; whereas, longer times indicated physical function more compromised. Initially, data were checked for normality by the KolmogoroveSrmirnov test. To compare the categories of BMI (normal x overweight x obese) was applied one-way ANOVA test and post-hoc Bonferroni to identify statistical differences. For comparison between groups (control x OA) was used independent t test. For all analyzes we adopted a significance level of 5% (p 0.05).