The fierce competition in the global silk market encourages the development and application of new biotechnologies in sericulture, such as cloning. The term “clone” in Greek means “branch”. A clone is an offspring of a single organism propagated without fertilization. All cloned individuals are genetically identical and are copies of each other. Clones are obtained in different ways. In case of the silkworm, this is a parthenogenetic development, which is an unnatural way of reproduction for the silkworm. Thermoactivation of an unfertilized greene at t0=46 0C during 18, leads to inhibition of the reduction division of meiosis in the silkworm germ cells. As a result, the eggs remain with a diploid set of chromosomes and develop as zygotes. Since the female cells in the sex chromosomes of the silkworm are heterogametic, only female parthenogenetic clones develop from thermally activated eggs. This feature makes silkworm clones extremely attractive for creating 100% pure hybrids. As the sericulture globally is based on the production of hybrids of the first generation only, in order to use maximum heterosis, the accuracy of preparation of hybrids is becoming particularly important.

Since the entire world's sericulture, to achieve maximum heterosis is based on the feeding of hybrids of only the first generation, therefore, operations for the preparation of pure hybrids are of particular importance. In Uzbekistan, the Sericulture Research Institute has developed new biotechnologies specifically to solve this problem, and genetically modified breeds and parthenogenetic clones have been created on their basis. The unfertilized eggs are thermally activated at t = 46°C for 18 minutes, and the reducing division of meiosis in the germ cells of the silkworm is hampered. As a result, the eggs remain with a diploid set of chromosomes and develop as zygotes. Since silkworm females are heterogamous by sex chromosomes, only female parthenogenetic clones develop from thermally activated eggs. Clonal-breed hybrids, characterized by increased viability of caterpillars – 93,5-98,0% (in the control – 90,0%), the high cocoon shell ratio – 22,1-23,8% (in the control – 22,5%), increased egg-bearing capacity - 622-639 pcs (in the control - 630 pcs), metric number of thread - 3344-4065 units (in the control - 3321), the synchronicity of caterpillar development, uniformity of cocoons, ease of preparation. The technology of thermal activation of unfertilized silkworm eggs for parthenogenetic development is not particularly difficult, therefore clones can reproduce the required number of generations and in an unlimited number of individuals. The second component for hybridization can be males of almost any breed. Clones, due to their genetic constancy, do not need breeding and breeding selection, they do not need to be divided by gender, because they are represented by only one female sex, and have high combinational ability and amicable development.

The creation and introduction into production of new breeds and hybrids that meet the needs of the world market and industrial enterprises through the development of selection methods for breeding stations and seed enterprises is of great scientific and practical importance. In this regard, the work of a number of local and international scientists is devoted to the selection and creation of new breeds and hybrids of mulberry silkworm on the basis of leading selection traits. The effectiveness of the artificial parthenogenesis method developed in our laboratory is that the effect applied suppresses the reduction division of egg cells. Also, the parthenogenetic genus immediately receives the same set of chromosomes and genes. However, ♀ clone × ♂ hybrid worms have a high viability, the cocoons are the same in shape and other characteristics, there is no work on the separation of the primary parent breed (parthenoclonus) for hybridization (because it consists of 100% only females), breeding at all stages work is not done (because all parthenoclon females are genetically the same and do not change by generation). It is also possible to obtain all the cocoons of parthenoclon in the extraction of cocoons, as their genetic homogeneity completely eliminates the sorting of cocoons in breeding stations and seed plants.

Worldwide, special attention is paid to the creation of high-tech silkworm breeds and hybrids of mulberry silkworms. Inbreed-breed hybrids with high technological performance of mulberry silkworm cocoon fiber have been created. Inbreed systems and new hybrids with fine silk fiber Kitayskaya 108, Ya-120, Ipakchi 1 x Ipakchi 2, Ipakchi 2 x Ipakchi 1 regionalized hybrids dry cocoon weight (0.715-0.841 g; control - 0.715-0.734 g), continuous cocoon fiber length (731-888 m; control - 744-776 m), cocoon fiber metric number (3020-3319 m/g; control - 3090-3103 m/g) proved to be significantly superior.

Natural silk was and remains the most elite and luxurious material. Silk is made from cocoons of the silkworm (Bombyx mori L.). The silkworm is part of the Holometabola group (insects with complete transformation). This means that the silkworm goes through several stages of development: egg, larva with four molts, pupa, butterfly. Each stage, depending on the breed and conditions of maintenance, is characterized by a certain duration and the so-called amity of development. In Uzbekistan, it is customary to carry out one feeding per year, timed to the beginning of the mulberry vegetation, therefore, tens of billions of caterpillars are simultaneously subjected to reproduction for 28–30 days. Changing the duration of any of the stages of development of the silkworm leads to destabilization of the feeding process and, as a result, to large material losses. Selection by motor activity, which implies the selection of the most active, and therefore the most viable individuals, leads to an acceleration of the metabоlism of the silkworm, synchronizes the development of a huge number of organisms at all stages of development, allows to coordinate with accuracy up to 1 day the work of all departments of the silk industry, accurately calculate time, human resources, the use of technical means and monetary costs for each stage and the entire cycle of reproduction of the silkworm.