A recent study found that hyperhomocysteinemia is associated with an increased risk for extracranial carotid artery stenosis, while another study demonstrated that hyperhomocysteinemia is a common risk factor for recurrent venous thrombosis. It seems as if an elevated circulating homocysteine is atherogenic as well as thrombogenic, possibly indicating extensive involvement of homocysteine in the pathogenesis of coronary heart disease.

Vacuum-compression therapy only slightly improves total skin perfusion and oxygenation, but not the nutritive microcirculation, being an essential factor in the occurrence of ischaemic symptoms. We therefore conclude that this instrument in its present form is not an aid in the treatment of lower limb ischaemia.