Homocysteine-An Atherogenic and a Thrombogenic Factor?

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doi:10.1111/j.1753-4887.1995.tb01486.x

Cited by 19 publications

(4 citation statements)

References 16 publications

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“…Significant plasma metabolites detected through differential metabolic screening suggested the potential involvement of vascular system in WB myopathy bird. Elevated homocysteine is associated as marker for cardiovascular disease (26) and can be atherogenic and thrombogenic (27). Trimethylamine N-oxide also has been associated as pro-atherogenic in humans.…”

Section: Discussionmentioning

confidence: 99%

Characterizing Woody Breast Myopathy in a Meat Broiler Line by Heat Production, Microbiota, and Plasma Metabolites

Maharjan¹,

Hilton²,

Weil³

et al. 2020

Front. Vet. Sci.

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Selection for quantitative traits in meat broilers such as breast yield and growth rate exert physiological pressure leading to ante mortem histological and biochemical alterations in muscle tissues. The poultry industry has recently witnessed a myopathy condition affecting Pectoralis major (breast muscle) of broilers, called woody breast (WB), an etiology still unclear to scientific community. A study was conducted to characterize the WB myopathy in a meat broiler line at its finishing phase (d 41) in terms of heat production (HP), microbiota and plasma metabolites. Two treatment groups were studied-WB affected (myopathy) and normal (non-myopathy) broiler; n = 20 in each group. Indirect calorimetry was utilized for HP measurement. Furthermore, body composition (BC) analysis was also performed using dual-energy x-ray absorptiometry (DEXA). Microbiota in ileal digesta was studied with PCR amplified 16s rRNA gene. LC-MS targeted metabolomics was performed to understand differential expression of plasma metabolites. Results showed that there was difference in fasting HP (P < 0.05) between these two treatment groups, with non-myopathy broiler producing more heat which was indicative of higher body protein content validated by higher protein: fat ratio by BC results. Less protein content in myopathy bird could be due to probable higher mixed muscle degradation occurring in lean tissue as marked by elevated 3-methylhistidine expression in plasma. Microbiota results showed unclassified Lactobacillus as predominant genus with higher abundance occurring in myopathy group; whereas at species level, L. acidipiscis was predominant bacteria for non-myopathy broiler. Differentially significant metabolites (P < 0.05) identified from plasma metabolome between these two treatment groups were homocysteine, cyclic GMP, trimethylamine N-oxide (TMAO), tyramine, carnitine, and acetylcarnitine, which were all associated to cardiovascular system. The findings suggest that more research in meat broilers could be opted toward delivering reduced vascularity issues to alleviate this myopathy condition.

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Section: Discussionmentioning

confidence: 99%

Characterizing Woody Breast Myopathy in a Meat Broiler Line by Heat Production, Microbiota, and Plasma Metabolites

Maharjan¹,

Hilton²,

Weil³

et al. 2020

Front. Vet. Sci.

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“…It has been suggested that some conventional risk factors of CAD operate by converting homocysteine into a more reactive form (4) and also that actions of homocysteine explain many key pathological changes of atherosclerosis (3). Homocysteine has been implicated in the pathogenesis of vascular disease (21).…”

Section: Discussionmentioning

confidence: 99%

“…It predisposes to premature athero-thrombotic occlusion (3,4) of coronary as well as other vessels (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Hyperhomocysteinaemia in Sri Lankan patients with coronary artery disease

Mendis¹,

Ranatunga²,

Jayatilake

et al. 2011

Ceylon Med. J.

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Papers AbstractObjective To determine the association between hyperhomocysteinaemia and coronary artery disease (CAD) in a sample of Sri Lankans. Design A case control study. Setting Asiri Hospital, Kirula Road, Colombo 5, Sri Lanka. Subjects 105 patients with coronary artery disease and 112 controls. Method Fasting serum homocysteine levels were measured in 105 patients diagnosed as having CAD and in 112 unmatched controls. All patients admitted with clinical, electrocardiographical, biochemical or echocardiographical evidence of CAD were included in the study. Controls were selected from subjects admitted for health screening. Results 105 patients with CAD and 112 controls (unmatched for age and sex) were studied. A serum homocysteine level in excess of 18.2 µmol/l was considered high. Confounding effects of other conventional risk factors for CAD were controlled using multivariate logical regression analysis. Conclusion Hyperhomocysteinaemia is significantly associated with CAD. Multivariate logistic regression analysis indicated that the association between hyperhomocysteinaemia and CAD was confounded by other risk factors. However, statistical analysis revealed a significant independent association between hyperhomocysteinaemia and CAD (adjusted odds ratio = 2.881).

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“…De nombreuses études montrent une association entre Hcy et l'augmentation des risques de maladies coronariennes, cérébrovasculaires et vasculaires périphériques (2,5,9,12,16,19,25,26). D'autres encore soulignent l'importance de l'Hcy modérée sur l'incidence des thrombo-embolies, à la fois artériels et veineux, ainsi que sur le risque de thromboses veineuses juvéniles ou récurrentes (2,11,13,15,27). L'Hcy est donc considérée comme un facteur de risque cardiovasculaire et cérébro-vasculaire indépendant (9).…”

Section: Introductionunclassified

Homocysteinemie et accidents vasculaires cerebraux ischemiques au chu campus de lome

Grunitzky¹,

Balogou²,

Barque-kombate³

et al. 2010

African Journal of Neurological Sciences

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L'hyperhomocystéinémie est un facteur de risque vasculaire indépendant et modifiable. Sa place dans les accidents vasculaires cérébraux ischémiques est mal connue en Afrique sub-saharienne. Objectifs Evaluer la prévalence et les facteurs de risque vasculaires associés à l'hyperhomocystéinémie chez des patients à la phase aigue d'une ischémie cérébrale. Methode Il s'agit d'une étude prospective réalisée pendant 12 mois dans le service de neurologie du CHU Campus, portant sur 145 malades victimes d'AVCI. Resultats Nous avions recensé 90 hommes et 55 femmes soit un sex-ratio de 1,6. L'homocystéinémie moyenne globale était de 19.33 µmol/l. L'homocystéinémie était normale chez 44.1 % des patients. L'hyperhomocystéinémie modérée avait été retrouvée chez 44.8 % des patients (n=65) et l'hyperhomocystéinémie intermédiaire chez 11 % (n=16). L'analyse multivariée entre la variable homocystéine (patients avec hyperhomocystéinémie, patients sans hyperhomocystéinémie) et les autres facteurs (sexe, âge, diabète et hypertension artérielle) ne révèle aucune corrélation significative. Enfin 84.9% de nos patients étaient hypertendus tandis que 15.1% présentaient l'hyperhomocystéinémie comme seul facteur de risque cérébro-vasculaire. Conclusion La présence de l'hyperhomocystéinémie chez 55.9 % des patients souffrant d'AVCI impose une prise en charge adéquate de ce facteur de risque vasculaire.

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Homocysteine-An Atherogenic and a Thrombogenic Factor?

Cited by 19 publications

References 16 publications

Characterizing Woody Breast Myopathy in a Meat Broiler Line by Heat Production, Microbiota, and Plasma Metabolites

Characterizing Woody Breast Myopathy in a Meat Broiler Line by Heat Production, Microbiota, and Plasma Metabolites

Hyperhomocysteinaemia in Sri Lankan patients with coronary artery disease

Homocysteinemie et accidents vasculaires cerebraux ischemiques au chu campus de lome

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