The study was carried out in Living Word Mission Hospital, Abayi, Aba, Abia State, Nigeria.The study was carried out among the ART and non-ART HIV patients attending the hospital.The CD4 count values were compared among the ART and the non-ART HIV patients to ascertain if there is any significant change among those on treatment and those not receiving treatment. The total number of subjects for the study was 97 (female=68, male=29). 77 subjects were ART HIV patients (female=55 and male=22) while 20 subjects were non-ART HIV patients (female=14 and male=6).The study showed significant increase (P<0.05) in the CD4 count of ART HIV patients more than non-ART HIV patients. The study equally showed significant increase (P<0.05) among the female ART HIV patients compared to the male ART HIV patients.The study showed that CD4 count should be done early to know when to start the treatment and the antiretroviral drugs have significant improvement in the immune system of the patients particularly the females.
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