Background: Recent reports from several parts of India indicate that there is a resurgence of scrub typhus. There have been a few studies analysing the association of various complications of scrub typhus with leukocyte count. The objective of this study was to study the association of various complications of scrub typhus with leukocyte count in children.Methods: A prospective study done at SPMCHI, SMS Medical College, Jaipur from August 2014 to November 2014. 75 Scrub typhus positive children were included in the study group. A detailed history of signs, symptoms, complications, demographic background was taken and relevant laboratory investigations done. The association between the complications of scrub and the total leukocyte count was studied, statistical analysis was done using Chi Square test.Results: Meningoencephalitis was most commonly seen complication in 14.7% followed by ARDS (9.3%), hepatitis (8%), AKI (6.7%), shock (6.7%) and myocarditis (1.3%). Meningoencephalitis and acute renal failure were more frequent among Scrub Typhus cases with leucopenia (p = 0.006, P = 0.011 respectively). It was observed that hepatitis was more frequent with leukocytosis, but was not statistically significant.Conclusions: Our study revealed that leukopenia has a significant association with meningoencephalitis and acute kidney injury.

Abstract:Less is known about the effect of perinatal asphyxia on fetal and neonatal thyroid hormone levels despite their importance. Only few studies carried out so far on this subject and even these have conflicting results. Aim of our study was to compare the serum levels of thyroid hormone (FT3&FT4) and TSH in term newborns with perinatal asphyxia and in healthy term newborns at 18 to 24 hr. after birth. And to find the association between severity of hypoxic-ischemic Encephalopathy and altered thyroid hormone (FT3&FT4) and TSH levels. It was a hospital based observational, Analytical, case-control study, 32 Term babies with perinatal asphyxia (as per NNF definition) were taken as cases and 32 healthy term newborns as controls. Thyroid hormones (FT3&FT4) and TSH levels from the blood collected between 18 and 24 hr. after birth were measured by Chemiluminiscence immunoassay. The results were analysed using chi square, ANOVA and post HOC test. P value <0.05 was considered significant. Mean value of S.FT3, FT4 & TSH were significantly lower in the asphyxiated group (2.99 + 0.91, 1.47 + 0.39 & 6.61 + 3.40) than control group (5.08 + 1.01, 2. 49 + 0.57 & 14.42 + 9.32). Asphyxiated neonates presented with significantly lower mean levels of FT3, FT4 and TSH with the advancing stages of HIE. Serum concentrations of FT3, FT4 & TSH were significantly lower in asphyxiated newborns than in normal newborns. Lower levels of FT3, FT4 & TSH had significant association with advance stages of HIE.

Chylothorax is the accumulation of lymphatic fluid in pleural space following traumatic injury to lymphatic vessels, systemic venous obstruction, dysfunction of the right ventricle, thrombosis of the duct, superior vena cava or subclavian vein, or postoperatively. A 2 ½-year-old male child operated for transposition of great arteries (TGA), tricuspid atresia (TA), and hypoplastic right ventricle 15 days ago developed chylothorax and left internal jugular vein thrombus. The child was initially managed conservatively with nutritional management, anticoagulation, and octreotide followed by interventional radiological management with lipoidol injection. Early suspicion and diagnosis are crucial. The management was difficult owing to a lack of proper guidelines. Further research is warranted.

Background-We planned the present study with objective of to find out correlation in vitamin B and folate levels with 12 clinical profile in children with ITS Methods- This Hospital based cross sectional observational study was conducted in, Sir Padampat Mother and Child Health Institute (SPMCHI),SMS Medical College,Jaipur. Results- Vitamin B and folate were reduced in children with generalized tremors, psychomotor retardation, delayed 12 milestones,presence of hepatomegaly and splenomegaly. Conclusion- All children with Infantile Tremor Syndrome should be screened for vitamin B and folate levels,high risk 12 children should be supplemented B and folic acid.

BACKGROUND- Exact incidence of ITS is not known but it was accounted for 0.2 to 2% pediatric hospital admissions in 1962 and reduced to 0.2% currently in India. Aims of this study to estimate Vitamin B level 12 and folate in children with Infantile Tremor Syndrome METHODS- This Hospital based cross sectional observational study was conducted in, Sir Padampat Mother and Child Health Institute (SPMCHI), SMS Medical College, Jaipur. RESULTS- The mean serum B level was highest in children aged 13-18 months (117.40 pg/ml) and was lowest in children aged 12 6-12 months (67.90 pg/ml). This difference in B level in different age groups was statistically not signicant (p>0.05). The mean 12 serum folate level was highest in children aged 6-12 months (17.32 ng/ml) followed by children aged 13-18 months (15.53 ng/ml) and was lowest in children aged >18 months (13.70 ng/ml). This difference in folate level in different age groups was statistically not signicant (p>0.05). CONCLUSION- Present study ndings suggest that serum vitamin B and folate levels are decreased in children with Infantile 12 Tremor Syndrome.