The study entitled "A Study on Performance of DOTS in a Private Medical College Hospital" was conducted in the area of ELURU town which is served by DMC of ASRAM Medical College to assess the performance of RNTCP at a premier tertiary level hospital of the state of Andhra Pradesh. This was both a hospital and community based prospective and follow-up study. Different technical indicators were considered to analyze the findings. Reference for sputum examination from ASRAM OPD (which include pulmonary medicine OPD) is 2.34% which is according to RNTCP norm>2%. Among the total new OPD registrations, 2.31% were chest symptomatic in the year 2011 and had undergone sputum smear examination for AFB. Among them 13.31% were detected to be sputum positive.91 of 122 cases that were diagnosed at ASRAM Medical College to be new smear positive were either referred to or transferred out to other DMC or TU respectively for DOTS. Ratio of patients among different categories in present study is found to be Cat-I: Cat-II is: 4.27:1 Retreatment case load of this DMC was 19% (RNTCP norm: ≤ 30%). A total of 58 patients had been registered in 2011 for DOTS under DMC of ASRAM Medical College. Among them 43 (74.13%) were males and 15 (25.86%) were females. Most of them (51.72%) belong to socioeconomically productive age group of 15-44 years. 65% of study subjects are illiterate or have low level of literacy which has a significant role in the spread and prevention of the disease in the community.68.97% of cases belong to low socioeconomic class which indicates that this disease still exists as a disease of poor men.