Cultivating with a hydroponic system is an alternative with increasingly limited agricultural land. Gamal leaves contain nutrients that are suitable to be used as hydroponic nutrients for lettuce (Lactuca sativa L.). This article will explain the effect of Gamal leaves nutrition on the growth and productivity of lettuce using the hydroponic method. The method used in this study was a Completely Randomized Design (CRD) consisting of 5 treatments namely P1 = (negative control) only water, P2 = 20% Gamal leaf nutrition, P3 = 30% Gamal leaf nutrition, P4 = leaf nutrition 40% Gamal and P5 = (positive control) AB-Mix nutrition. The parameters observed consisted of plant height, number of leaves, leaf width and gross weight. Analysis with One Way ANOVA assisted by SPSS 17 and LSD advanced test. The results on the parameters observed and analyzed carried out had a real effect on all parameters. Gamal leaf nutrition treatment on plant height P4 and P2 were not significantly different from P2, the number of leaves and leaf width of P2, P3 and P4 were not significantly different, whereas the wet weight P4 had the highest value which is significantly different from other treatments.