Background: Wound healing is a complex process, and selecting an appropriate treatment is crucial and varies from one wound to another. Among injuries, burn wounds are more challenging to treat. Different dressings and scaffolds come into play when skin is injured. These scaffolds provide the optimum environment for wound healing. With the advancements of nanoengineering, scaffolds have been engineered to improve wound healing with lower fatality rates. Objectives: Nanoengineered systems have emerged as one of the promising candidates for burn wound management. This review paper aims to provide an in-depth understanding of burn wounds and the role of nanoengineering in burn wound management. The advantages of nanoengineered scaffolds, their properties, and their proven effectiveness have been discussed. Nanoparticles and nanofibers-based nanoengineered therapeutic scaffolds provide optimum protection, infection management, and accelerated wound healing due to their unique characteristics. These scaffolds increase cell attachment and proliferation for desired results. Results: The literature review suggested that the utilization of nanoengineered scaffolds has accelerated burn wound healing. Nanofibers provide better cell attachment and proliferation among different nanoengineered scaffolds due to their 3D structure mimics the body's extracellular matrix. Conclusion: With the application of these advanced nanoengineered scaffolds, better burn wound management is possible due to sustained drug delivery, better cell attachment, and an infection-free environment.

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Sodium alginate and hyaluronic acid are being used extensively in wound care applications for their exceptional properties, including gelation, biocompatibility, exudate absorption, and the ability to provide a moist environment to the wound bed that accelerates healing. This research work presents the potential of developing silver and zinc ions loaded bioactive fibers for wound care applications with improved absorption, swelling (gelling), and antibacterial properties. The effect of loading silver and zinc on alginate/hyaluronic acid biofiber absorption, swelling (gelation), tensile and antibacterial activity were analyzed. It was found that the addition of silver and zinc salts improved the absorption, tensile, and gelation properties of alginate/hyaluronic acid fibers. Zinc-containing fibers exhibited superior properties to silver-containing fibers. The presence of hyaluronic acid influenced the release of silver and zinc ions in various liquid media with a maximum of 26 g/g absorption was observed which suggested the good wound exudate absorption capacity of the developed fibers. The developed fibers showed good antibacterial activity against Staphylococcus aureus and Escherichia coli strains.