We studied the effect of antibodies to glutamate and GABA (active immunization with conjugates of glutamate--bovine serum albumin and GABA--bovine serum albumin) on the course of combined water-immersion stress in C57Bl/6 mice. Preimmunization of animals with the conjugate of glutamate--bovine serum albumin was accompanied by strong production of antibodies to glutamate, which reduced the majority of signs of the stress response. Antibodies to GABA had no effect on the development of stress.