The main provisions, proposed tools and practical recommendations for managing the intersectoral potential for industrial development under Industry 5.0 are outlined in the article. The research methodology includes a systematic approach to the formation and management of the cyber-physical-social system with an emphasis on the cross-industry nature, the interdisciplinarity of the foundation and the transdisciplinarity of Industry 5.0; value, cyber-socio-techno-cognitive, human-centric and socio-centric approaches; platform interest. Choice evolution of industries and their objects (physical systems of Industry 1.0 - 3.0, cyber-physical system of Industry 4.0, cyber-physical-social system of Industry 5.0). The article provides a description of various factors, further analysis of which allows us to state that Industry 4.0 is not the basis for achieving higher development goals expected by 2030. The capabilities of the main characteristics, goals and opportunities of Industry 4.0 and Industry 5.0 are compared. It is concluded that Industry 5.0 does not equally represent the next industrial revolution, how many attendants join Industry 4.0 technologies strengthening cooperation between humans and robots. Technologies, possible tools and practical applications of Industry 5.0 are systematized. Priority measures aimed at preparing for Industry 5.0 implementation in a natural ecosystem, scientific and technological development based on proactive import substitution are proposed.