Goal. To study the toxicity of the modern variety of insecticides from different classes of chemical substances at the level of the mean concentration (СК50, %) of the active substance for the common cereal aphids, cabbage flea, rape blossom weevil, common spider mite. Based on these data to determine the rate of resistance of natural populations of these species of phytophagous arthropods to insecticides. Methodology. The sensitivity of phytophagous arthropods was studied on natural populations collected on crops of winter wheat, canola, soybeans in the Kiev region in 2015—2018. For the poisoning of cereal aphids and mites using the method of immersion of the populated lists wheat and soybeans, and flea beetles and pollen beetle — dip them in a gauze bag for 3 seconds in the appropriate solution of insecticides. Were taken 24 hours after poisoning. Toxicological parameters were calculated by using Proban. Results. Identifies the different sensitivity of the natural arthropod populations to current insecticides. In terms of the mean concentration (СК50, %) of the active substance rapeseed pollen beetle were most sensitive to Configure, while the rest of the drugs is almost the same. Over the years research is more resistant to Decis Profi turned ordinary spider mites. This pest was a higher resistance. Conclusions. The sensitivity of arthropods to insecticides of different chemical classes depends on the characteristics of the pest and the properties of the drug. Indicators of resistance are determined by the biology of the phytophage and terms of use of insecticide. The highest PR was observed for polyvoltine species (aphids, mites). Low levels of resistance to phytophagous pyrethroid insecticides can be explained by two factors: a smaller volume of use or reversion (return of chuvstvitelnosti to the initial level).