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Gorden and Roth (1969 a) have reported that the ratio of "big" over "little" insulin increases in response to an oral glucose load. During the first 30 minutes, it does not reach 5% of the total insulin. Conversely, 90 to 120 min after the glucose load, "big" insulin represents 5 to 29% of the total insulin. The same authors observed that the proportion of "big" insulin increases at a11 times in obese hyperinsulinemic subjects, this increase being already important after 15 min (Gordon and Roth 1969 a, 1969 b). This paper reports the effect of an experimental rise of FF A on the quality of the insulin secretion in man, being accepted that "big" insulin represents proinsulin chain or a pro insulin intermediate form (Sherman, Gordon. Roth and Freychet 1971, Steiner. Clark, Nolen. Rubenstein, Margoliash, Me/ani andOyer 1970).