The expression of molecular markers characterizing activity of the tumor process and metastases (proliferation marker Ki-67, angiogenesis marker CD34, and lymphangiogenesis markers podoplanin and LYVE-1) was assessed by immunohictochemical method in the primary tumor specimens collected during surgery for cutaneous melanoma (40 patients). Proliferative activity of the tumor tissue and volume density of peritumoral blood and lymph vessels increased with increasing tumor malignancy, which could indicate the risk of metastases.

Objective. To evaluate the prognostic significance of metabolic syndrome (MS) in the development of colorectal cancer (CRC) using various MS criteria in Novosibirsk population. Materials and Methods. The study was designed as nested «case-control». Baseline population cohort (9360 men, women aged 45-69) was examined in the HAPIEE project and followed-up during 11 years. The "cases" included all subjects, who had CRC during 11-year follow-up according to the Register of Cancer (n=99, M-52, M-47). The matched control group (2/1) was selected from HAPIEE cohort (n=198, m-104, w-94). The prospective study of CRC was supported by RSF. MS criteria were determined in accordance to VNOK (2009), IDF (2005, NCEP ATP III (2001). Statistical package SPSS v.11.0 was used. Logistic regression was used to estimate the association between MS and risk of CRC. Results. Women with glucose levels ≥6.1 mmol/l had 3 times higher 11-year risk of CRC then those with glucose <6.1 mmol/l (OR=3.11; 95%CI:1. 23-7.87, VNOK, 2009; OR=3.20; 95%CI:1.27-8.08, NCEP ATP III, 2001). Blood pressure (BP) ≥130/85 mmHg was associated with decreased risk of CRC in women and in both sexes, but the relationship became insignificant after controlling for antihypertensive treatment. Other components of the MS were not significantly associated with CRC risk. Conclusions. In studied sample the 11-year risk of developing CRC was significantly increased in women with elevated glucose levels. The negative relationship between elevated BP and the risk of CRC in women and both sexes became insignificant when adjusted for antihypertensive treatment; this finding requires further exploration. Keywords: metabolic syndrome, colorectal cancer, components of the metabolic syndrome, colon and rectum cancer.

No abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a progressive, long-lasting and often irreversible condition characterized by pain, numbness, tingling, and sensitization to cold in the hands and feet that affects 30 to 40% of patients undergoing chemotherapy. This leads to disability and a deterioration in the quality of life of patients against the background of the absence of tumor progression, representing a serious side effect of treatment. There are certain clinical risk factors for CIPN, but none of them accurately indicates the severity and possibility of developing the disease in oncologic patients. Prediction, early detection and monitoring of side effects of chemotherapy is of great importance in the treatment of cancer patients. Further research in this field will make it possible to correctly and effectively plan and carry out treatment and rehabilitation arrangements using preventive technologies.

Neurotoxicity is one of the common side effects of anticancer chemotherapy. This pathology has a detectability of 38–90%. In some cases, it causes not only a significant decrease of life quality but also decrease of dose of cytostatics. Therefore, the tasks of early diagnosis, prevention and treatment of neurotoxicity are very relevant. Sensors underlying detection, especially neuroinflammation processes, are needed to develop an effective therapy for chemotherapy-induced neurotoxicity. The purpose of this topic is to study the results of chemotherapy studies on changes in the activity of proinflammatory cytokines. In this regard, the study of behavioral societies in neuropathic pain in animal models is of great importance. It was revealed that various manifestations of inflammation of pro-inflammatory cytokines, chemokines, damage to the dorsal ganglion or distal nerve endings are increasingly being detected. Detection of chemically induced peripheral neuropathy using animal models is necessary for in-depth identification of the cause-and-effect mechanisms of its development and selection of new, more effective methods of treatment.