TLT has a positive effect on the basic patterns of IS pathogenesis and biochemical predictors allow to rationalize the treatment.

Aim: identification of risk factors of hemorrhagic transformation (HT) after intravenous thrombolytic therapy. Patients and methods: the study included 100 medical records of patients, who underwent thrombolytic therapy. Patients were divided into two groups according to the outcome: 89 patients with HT and 11 patients without HT. Clinical and demographic characteristics of patients were analyzed, including neurological status assessment using NIHSS, Rankin, Rivermead and Waterloo scales. Results: among patients with HT 54.5% were smokers, compared to 29.2% in no HT group (p < 0.05). Significant differences in Rankin, Rivermead and Waterloo scales on admission, after the intervention and at discharge were observed (p < 0.05). Conclusion: smoking is as a significant risk factor of HT, which should be taken into account in the development of thrombolytic therapy programs.

Despite significant advances in the treatment of ischemic stroke, which were achieved due to the implementation of the program to combat stroke, the mortality and disability rates in this pathology continue to remain high. The identification of biochemical markers of the unfavorable clinical course of cerebral infarction is quite urgent, since it can be a useful addition to the optimization of predicting the outcomes of acute cerebrovascular catastrophe and the effectiveness of thrombolytic therapy.