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I want to thank my family for their continuous and unconditional support during every stage of my studies, and my advisors, PhD Álvaro Ángel Orozco Gutiérrez and PhD Óscar Alberto Henao Gallo, for their help and indispensable guidance during the development of this project. I am also thankful to the MSc in Electrical Engineering program at UTP and to the Automática research group, especially to PhD Mauricio Alexander Álvarez López and PhD Genaro Daza Santacoloma for their valuable insight on several aspects of this project. This work was funded by Colciencias under the project Desarrollo de un sistema efectivo y apropiado de estimación de volumen de tejido activo para el mejoramiento de los resultados terapéuticos en pacientes con enfermedad de Parkinson intervenidos quirúrgicamente, with code 1110-569-34461.

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