Chamomile extracts are mainly used because of their antiinflammatory action.Well-known are the antiphlogistic properties of chamazulene and (-)-alpha-bisabolol. So far the effects exerted by bisabolol oxides and by the synthetic racemic compound of bisa-bolo1 have been unclear. Therefore, it was not possible t o determine the relevance of these substances in connection with the standardization of chamomile extracts and preparations.Experiments conducted in rat paw edema (carrageenin) have shown that the antiphlogistic effect exerted by (-)-alpha-bisabolol is considerably more marked than that of the bisabolol oxides A and By and even more pronounced than that of bisabolon oxide and both (+)-alpha-bisabolol and ( + )-alpha-bisabolol.Moreover, that antiphlogistic effect of (-)-alpha-bisabolol could be confirmed in a number of further experimental models, e. g. in adjuvant arthritis of the rat, in UV-erythema of the guinea pig and in yeast fever of the rat. In addition, (-)-alpha-bisabolol reduces the production of mucopolysaccharides in the cell cultures.As was evidenced in the experiments, the content of (-)-alpha-bisabolol is of relevance when assessing the antiphlo-Heruntergeladen von: University of Illinois. Urheberrechtlich geschützt. Literatur Adresse: Dr. 0. Isaac, DaimlerstraJe 25, 0-6000 FrankfurtlM.

While it is known that chamomile contains matricine, so far it was not clear whether this chamazulene precursor is as pharmacologically active as chamazulene itself. As guajazulene, moreover, is frequently

In the course of studies on tranquilizers, new non-benzodiazepine-like compounds were synthesized. These are 1-(3,4,5-trimethoxyphenoxy)-3-[4-(2-methoxyphenyl)piperazinyl]prop an-2-ol (INN: enciprazine) and derivatives thereof which were screened pharmacologically in order to evaluate their central nervous system activity. Compounds with marked antiaggressive and anxiolytic properties but without dependence potential could be detected. Enciprazine was selected for clinical investigations.

Die basischen Terpenäther (Ia)‐(Ic) und (II)‐(IX) werden durch Reaktion von Terpenalkoholen mit Natriumamid und den entsprechenden Alkylchloriden dargestellt.

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