Pharmakologische Untersuchungen von Kamillen–Inhaltsstoffen – II. Neue Untersuchungen zur antiphlogistischen Wirkung des (–)–α–Bisabolols und der Bisabololoxide

Abstract

Chamomile extracts are mainly used because of their antiinflammatory action.Well-known are the antiphlogistic properties of chamazulene and (-)-alpha-bisabolol. So far the effects exerted by bisabolol oxides and by the synthetic racemic compound of bisa-bolo1 have been unclear. Therefore, it was not possible t o determine the relevance of these substances in connection with the standardization of chamomile extracts and preparations.Experiments conducted in rat paw edema (carrageenin) have shown that the antiphlogistic effect exerted by (-)-alpha-bisabolol is considerably more marked than that of the bisabolol oxides A and By and even more pronounced than that of bisabolon oxide and both (+)-alpha-bisabolol and ( + )-alpha-bisabolol.Moreover, that antiphlogistic effect of (-)-alpha-bisabolol could be confirmed in a number of further experimental models, e. g. in adjuvant arthritis of the rat, in UV-erythema of the guinea pig and in yeast fever of the rat. In addition, (-)-alpha-bisabolol reduces the production of mucopolysaccharides in the cell cultures.As was evidenced in the experiments, the content of (-)-alpha-bisabolol is of relevance when assessing the antiphlo-Heruntergeladen von: University of Illinois. Urheberrechtlich geschützt. Literatur Adresse: Dr. 0. Isaac, DaimlerstraJe 25, 0-6000 FrankfurtlM.

Zur Stereochemie der Bisaboloide aus Matricaria chamomilla L/On the Stereochemistry of the Bisaboloids from Matricaria chamomilla L.

“…: -46,9 [4])-IR-Spektrum: Identisch mit den publizierten Daten [19]. MS-Spektrum: Identisch mit den publizierten Daten [6].…”

In Vitro Antichemotactic Activity of Chamomilla recutita Hydroethanol Extract

“…Being one of the most well documented medicinal plants, several of its potentially biologically active chemical constituents have been described, some of them isolated from its essential oil (Isaac, 1979;Jakovlev et al, 1979Jakovlev et al, , 1983Safayhi et al, 1994;Gerritsen et al, 1995;Miller et al, 1996;Rekka et al, 1996;Avallone et al, 2000). For example, its flavonoids have been shown to exert benzodiazepine-like activity (Viola et al, 1995;Avallone et al, 1996Avallone et al, , 2000 as well as phosphodiesterase inhibitory action, leading to increased levels of cAMP (Beretz et al, 1978;Picq et al, 1989).…”

Additive Wirkung von Heparin und Levomenol bei Neurodermitis

“…Diese Voraussetzungen werden bei guter Verträglichkeit von den Wirkstoffen Heparin und Levomenol erfüllt. Levomenol, auch (-)-α-Bisabolol genannt, hat bei topischer Applikation ausgeprägt antiphlogistische und wundheilungsfördernde Eigenschaften [1,2]. Die aus pharmakologischen Untersuchungen bekannten antientzündlichen, wundheilungsfördernden und antiallergischen Eigenschaften von Heparin (z.…”