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A new series of 4-aryl and 4-alkyl-4-N-arylamine-1-butenes (homoallylamines) were synthesized and some of them transformed to 4-aryl or alkylquinolines. All of them showed strong antifungal activities against human pathogenic fungi in vitro, being Epidermophyton floccosum the most susceptible species

Chemistry of Functionalized Benzazepines.Part 5. Synthesis and Chemical Transformation of the 1,2,4,5-Tetrahydrospiro[3H-2benzazepine-3,1'-cycloalkanes].-A number of new spiroderivatives of tetrahydro-2-benzazepine (III) are synthesized by reaction of imines (I) with allyl Grignard reagent (II) and subsequent cyclization. Nitration and bromination of (III) take place regioselectively on position C-8 of the phenyl ring giving (IV) and (V), respectively. Alkylation and acylation provides the corresponding N-substituted derivatives (VII) and (IX), respectively. Oxidation of (IIIa) with Na 2 WO 4 /H 2 O 2 affords the novel nitrone (X). -(KOUZNETSOV, V.; PALMA R, A.; SALAS, S.; VARGAS, L. Y.; ZUBKOV, F.; VARLAMOV, A.; MARTINEZ, J. R.; J. Heterocycl. Chem. 34 (1997) 5, 1591-1595; Lab. Sint.

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Reduction of the Pyrimidine Ring: Regio-and Stereoselective Synthesis of 1,3-Diamine Derivatives.-The N,N'-disubstituted 1,3-diamines (II) are produced by stereoselective reductive cleavage of the 1-butyl-1,2-dihydropyrimidines (I) which are prepared according to known procedures.The method is also applied to the fused pyrimidines (III), yielding the diamines (IV) or the octahydropyrrolo(1,2-a)pyrimidines ( V) depending on the reduction conditions employed.-(BARLUENGA, J.; TOMAS, M.; KOUZNETSOV, V.; JARDON, J.; RUBIO, E.; Synlett (1991) 11, 821-823; Dep. Quim. Organomet., Fac. Quim., Univ., 33071 Oviedo, Spain; EN)