Relevance: Treatment of patients with hepatocellular cancer remains a complex problem in modern oncology. Purpose: To evaluate the effectiveness of chemoembolization in hepatocellular cancer and metastatic liver disease. Results: During and after the procedure, the risk of complications was minimal: in 2 cases (0.25%), liver necrosis and death from cardiovascular insufficiency were recorded after five therapy courses. Eleven patients (23.9%) with a continued tumor growth showed a negative response and were administered symptomatic treatment. Conclusion: In primary hepatocellular cancer and metastatic liver lesions, chemoembolization is one of the priorities in interventional radiology and a stage of complex treatment. This method is low-traumatic due to a minimal toxic effect of the chemotherapy drug. This method is indicated for inoperable liver tumors because a high concentration of an anticancer drug is delivered right to the focus and ensures a prolonged tumor exposure, with minimal risk of complications during and after the procedure. In our observations, complications in the form of necrosis and death occurred in 2 (0.25%) cases