The purpose of this research was to develop a matrix-type transdermal therapeutic system containing drug propranolol hydrochloride with different ratios of hydrophobic (eudragit's) polymeric systems by the solvent evaporation technique by using 30 % w/w of di-butyl phthalate to the polymer weight, incorporated as plasticizer. The physicochemical compatibility of the drug and the polymers studied by infrared spectroscopy suggested absence of any incompatibility. Formulated transdermal films were physically evaluated with regard to thickness, weight variation, drug content, flatness, folding endurance moisture. All prepared formulations indicated good physical stability. In-vitro permeation studies of formulations were performed by using Franz diffusion cells.It shown that drug release follows zero order and the mechanism of release is diffusion from the polymer.

Liposomes have been widely investigated since 1970 as drug carriers for improving the delivery of therapeutic agents to specific sites in the body. As a result, numerous improvements have been made, thus making this technology potentially useful for the treatment of certain diseases in the clinics. The success of liposomes as drug carriers has been reflected in a number of liposome-based formulations, which are commercially available or are currently undergoing clinical trials. This review is focused on the various aspects of liposomes starting from the evolution and the current research including the detailed summary such as classification, methods of preparation, characterization and the potential use of liposomes in the treatment of various diseases and the various sites to which these are targeted.Liposomes have covered predominantly medical, albeit some non-medical areas like bioreactor, catalysts, cosmeticsand ecology. However, their predominance in drug delivery and targeting has enabled them to be used astherapeutics tool in fields like tumor targeting, gene and antisense therapy etc.

The objective of the present study was to formulate site specific drug delivery of Cromolyn sodium using karaya gum. The microspheres were prepared by both ionic gelation method and emulsion-ionic gelation. Microspheres were characterized by FT-IR spectroscopy, Differential scanning calorimerty and evaluated by scanning electron microscopy (SEM), particle size analysis, entrapment efficiency and in-vitro drug release studies in different simulated gastric fluids. Stability studies were carried out for one month at 40±2 0 C/75±5% RH. The SEM images revealed the surface morphology was rough and smooth for core and coated microspheres, respectively. The optimized batch (IK1,EK8) coated microspheres (15%w/v) for 24hr exhibited 95.24± 3.48 %and 99.74± 2.82% drug release, respectively. The drug release was quick in presence of rat caecal contents because of the enzymatic effect on the polymer matrix. The drug release from all karaya gum microsphere formulations followed higuchi kinetics. Moreover, drug release from eudragit S-100 coated microspheres followed the korsmeyer-peppas equation with a fickian kinetics mechanism. Finally stability studies suggested the change in entrapment efficiency and in-vitro drug release of microspheres was minimal, indicating good stability of the formulation.

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Oral analgesics are commonly prescribed for the treatment of acute and chronic pain, but these agents often produce adverse systemic effects, which some times are severe ,so topical administration of analgesics is an alternative method. The aim of present work is to develop semi solid preparations of natural analgesics like camphor. Three different strengths were prepared which are 25mg,50mg,100mg in two different bases that are hydrophilic and hydrophobic. All the prepared formulations were evaluated for PH, spreadability, diffusion studies. The selected formulations were evaluated for in-vivo studies in comparison with marketed preparations .The finalized preparation was kept for stability studies according to ICH guidelines.