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The effect of Gymnema montanum leaves on alloxaninduced hyperlipidemia was studied in male Wistar rats. Ethanolic extract of G. montanum leaves was administered orally and different doses of the extract on blood glucose, serum and tissue lipids, hexokinase, glucose-6-phosphatase, thiobarbituric acid-reactive substances (TBARS), hydroperoxides, and glutathione in alloxan-induced diabetic rats were studied. G. montanum leaf extract (GLEt) at doses of 50, 100, 200 mg/kg body weight for 3 weeks suppressed the elevated blood glucose and lipid levels in diabetic rats. GLEt at 200 mg/kg body weight was found to be comparable to glibenclamide, a reference drug. These data indicate that G. montanum represents an effective antihyperglycemic and antihyperlipidemic adjunct for the treatment of diabetes and a potential source of discovery of new orally active agent for future therapy.Keywords Alloxan Diabetes; Blood Glucose; Carbohydrate Enzymes; Gymnema montanum; Lipids Experimental diabetes in animals has provided considerable insight into the physiologic and biochemical derangements of the diabetic state. Many of the derangements have been characterized in hyperglycemic animals. Significant changes in lipid metabolism and structure also occur in diabetes [1]. In these cases, the structural changes are clearly oxidative in nature and

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