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Peculiarity of Ultrastructure and45 Ca Methabolism of Osteoclasts in Conditions of Hind Limb Unloading and Microgravity. Rodionova N. V., Oganov V. S. -Using methods of electron microscopy, morphometry and cytochemistry the peculiarities of ultrastructure of osteoclasts and resorptive processes of the mineralized matrix in spongy bone of the rat femoral bone metaphyses following the experimental hind limb unloading model (28 days), as well as in rats exposed on American Space Station SLS-2 (2 weeks) were studied. The methods of light and electron microscopy radioautography Îñîáåííîñòè óëüòðàñòðóêòóðû è ìåòàáîëèçìà45 Ñà îñòåîêëàñòîâ â óñëîâèÿõ ðàçãðóçêè çàäíèõ êîíå÷-íîñòåé è ìèêðîãðàâèòàöèè. Ðîäèîíîâà Í. Â., Îãàíîâ Â. Ñ. -Ñ èñïîëüçîâàíèåì ìåòîäîâ ýëåê-òðîííîé ìèêðîñêîïèè, ìîðôîìåòðèè è öèòîõèìèè èçó÷åíû îñîáåííîñòè óëüòðàñòðóêòóðû îñòåîêëàñòîâ è ïðîöåññîâ ðåçîðáöèè ìèíåðàëèçèðîâàííîãî ìàòðèêñà áåäðåííîé êîñòè êðûñ â óñëîâèÿõ ìîäåëè îïîðíîé ðàçãðóçêè çàäíèõ êîíå÷íîñòåé (28 ñóòîê), à òàêaeå ó êðûñ ïîñëå ïðåáûâàíèÿ íà àìåðèêàíñêîé êîñìè÷åñêîé ñòàíöèè SLS-2 (2 íåäåëè). Ïðèìåíåí òàêaeå ìåòîä ñâåòîâîé è ýëåêòðîííî-ìèêðîñêîïè÷åñêîé ðàäèîàâòîãðàôèè ñ 45 Ca. Ðåçóëüòàòû èññëåäîâàíèÿ ïîêàçàëè, ÷òî â çîíàõ àäàïòèâíîãî ðåìîäåëèðîâàíèÿ ïðîöåññû ðåçîðáöèè è äåñòðóêöèè êîñò-íîãî ìàòðèêñà óñèëèâàþòñÿ ïðè îïîðíîé ðàçãðóçêå. Ýòî ïðîèñõîäèò ïóòåì èíòåíñèôèêàöèè ôóíêöèîíàëüíîé àêòèâíîñòè îñòåîêëàñòîâ (â óñëîâèÿõ ìèêðîãðàâèòàöèè íàìè çàðåãèñòðè-ðîâàíû «ãèãàíòñêèå» îñòåîêëàñòû). Äèíàìèêà âêëþ÷åíèÿ 45 Ñà â îñòåîêëàñòû ñâèäåòåëüñòâóåò î ïðÿìîì ó÷àñòèè êëåòîê â ïåðåíîñå êàëüöèÿ èç ðåçîðáèðîâàííîãî êîñòíîãî ìàòðèêñà â ìåaeêëåòî÷íîå ïðîñòðàíñòâî è èíòåíñèôèêàöèþ ýòîãî ïðîöåññà ïðè ñíÿòèè îïîðíîé íàãðóçêè.