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In the work composite films based on chitosan and single-walled carbon nanotubes (0.01%, 0.1%, 0.5% and 1%) were obtained. The electrical and mechanical properties of the composite films were measured. It was shown that a film with 1% SWCNT has sufficient electrical conductivity and optimal mechanical properties for the bioactivity of a culture of human dermal fibroblasts. It has been established that treating a film in a corona discharge changes the structure of the film and increases the adhesion and proliferation of human dermal fibroblast cells.

In this work, an electrically conductive composite based on thermoplastic polyimide and graphene was obtained and used as a bioelectrode for electrical stimulation of human dermal fibroblasts. The values of the electrical conductivity of the obtained composite films varied from 10−15 to 102 S/m with increasing graphene content (from 0 to 5.0 wt.%). The characteristics of ionic and electronic currents flowing through the matrix with the superposition of cyclic potentials ± 100 mV were studied. The high stability of the composite was established during prolonged cycling (130 h) in an electric field with a frequency of 0.016 Hz. It was established that the composite films based on polyimide and graphene have good biocompatibility and are not toxic to fibroblast cells. It was shown that preliminary electrical stimulation increases the proliferative activity of human dermal fibroblasts in comparison with intact cells. It is revealed that an electric field with a strength E = 0.02–0.04 V/m applied to the polyimide films containing 0.5–3.0 wt.% of the graphene nanoparticles activates cellular processes (adhesion, proliferation).

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