As a result of studies, information of the influence of cAMP and nelarabine on the processes of fibrillation of insulin molecules is presented. In vitro experiments revealed that cAMP and nelarabine reduces the process of fibrillation.

As a result of the research, data on the dynamics of fibrillation of insulin molecules under different temperature conditions are presented. The influence of the pH of the medium and mechanical action on the processes of amyloid formation is also studied. In vitro experiments revealed three stages of fibrillation of insulin molecules.

The influence of temperature and mechanical factors on insulin fibril formation was revealed. It was found that during the incubation of insulin for 30 hours, the concentration of fibrils increases compared to the control. It was shown that the incubation of insulin with zinc chloride led to a decrease in insulin fibril formation.