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A method for the preparation of new 3 nitro 1,2,4 triazole derivatives has been suggested based on modification of the N hydroxymethyl group by nitration and nucleophilic substitution reactions. Thermal stability of 3 nitro 1,2,4 triazole N nitroxy and N azidomethyl deriva tives, as well as of dinitrates, 5,5´ dinitro 2,2´ bisnitroxymethyl 2H,2´H 3,3´ bi(1,2,4 triazole) and (nitromethylene)bis(1,2,4 triazole), has been studied.

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Nonannulated tetrazolylpyrimidines in the structure of which the heterocyclic fragments are separated by hydrazinocarbonylmethyl, methylpyrazolyl groups or a sulfur atom were synthesized. Some of these compounds showed moderate in vitro activity against H1N1 subtype of influenza A virus. The selectivity index of the anti-influenza action of {5-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-1H-tetrazol-1-yl}acetic acid, which has very low cytotoxicity, was twice as high as the selectivity index of the reference drug rimantadine.