The aim of this study was to determine the effect of supplement «Press-Acid» on some parameters of mineral and protein metabolism and resistance of piglets. The study was done in condition «Meta» on two groups of piglets of the F-1 (BWхL) genotype. There were determined indexes of bacterial and lysocim activity of blood serum, calcium and phosphorus in piglets at the age of 21–30–45–75 days. Effect of supplement on the growth rate, morbidity and safety of pigs were revealed. We used hygienic, zootechnical, hematological, biochemical, immunological and statistical methods of analysis. The influence of «Press-Acid», which consist of formic, lactic, citric and fumaric acids, was established for the first time. The concentration of calcium in blood serum of experimental group of piglets were lower than in animals of control group. The level of phosphorus increased in blood serum of experimental animals on 11.83% (30 day), on 3.74% (45%), on 17.65% (75 day) respectively. Concentration of hemoglobin and the amount of erythrocytes increased on 11.8% and on 1.82% (30 day) in animals that feed the supplement. There were established the increase of viability of the pigs with gastro-intestinal diseases which were given the supplement in comparison with that, who did not feed it. Severity of diseases was determined using the Melenberg coefficient which did not higher than 1.2–2.4 score, it was lower on 6,0–9,3 unit than in control group. Using the supplement allowed to increase the intensity of growth of piglets by 3.7% (45 day) and 9.4% (75 day) respectively. Concentration of total protein, albumines and globulins increased on 8.66%, 9.90%, 7.3% respectively. The activity of alaninaminotransphaerasae in the blood serum of experimental animals were lower on 3.45% than in control piglets. Lysocym and bacterial activity of blood serum were higher in experimental group of piglets. Feeding piglets with addition supplement Press Acid promotes higher grow rates in experimental animals, that can be explained increases of oxidative-reducing processes in them organism. Feeding piglets with acidifier «Press-Acid», «Nifulin», zinc oxide, probiotics «Lactisan Complex» promotes growth energy, increase of morphological, biochemical and immunological parameters which indicates a higher level of oxidative reaction in the body. A low coefficient of Melenberg is recorded in the piglets at the age of 1 day. Safety was within 92.1–97.0%. That indicates a more successful elimination of complexes of protein, mineral substances, humoral protection in blood of experimental group of animals.

Mycotoxins cause severe diseases in organisms of human and animals. They are difficult to diagnose, cause great economic damage. Sorbents are able to effectively bind and remove from the body through the digestive tract with a therapeutic or prophylactic purpose various endogenous and ekzogenous substances, microorganisms and they toxins, supermolecular structures and cells. The aim of the work is to study the effectiveness of use of Alfasorb for the neutralization of mixed fodders affected by mycotoxins and they impact on blood’s indexes and productive qualities of piglets of Large White Breed. Experience was conducted on 30 ty piglets. Animals of the control group received mixed feed that was produced in the conditions of the farm. The pigs of experimental group in addition to the basic diet received Alfasorb. We determined blood’s indexes for study the effect of feed additive Alfasorb on the physiological state of animals at 4 months of age. A morphological and histological study of liver was carried out. The analysis of the average daily weight gain of piglets showed that it was higher in period of growth in the animals of experimental group. In the animals of the experimental groups there was an increase in the number of red blood cells in comparison with the control. An unreliable decrease in blood serum levels which characterize the level of intermediate metabolism of proteins in the body (content of urea, creatinine and common bilirubin) was established in the animals of the experimental group as compared to the control group respectively by 22.83% ( td = 0.98, P ≤ 0.05), 7.12% (td = 1.92, P ≤ 0.05) and by 20.54% (td = 0.86, P ≤ 0.05). Most hepatocytes had large nucleus and intense color of the cytoplasm. This indicates the absence of alterative processes in the body. The results of the studies make it possible to assert that the inclusion the 0.2% Alfasorb to the compound of feed which contaminated with mycotoxins significantly reduces their negative effect on the piglets organism, has a positive effect on the growth rate, on the course of metabolic processes, also it promotes an increase in the liver of medium-sized hepatocyte nuclei, stimulates biosynthetic processes in that cells and ensures the formation of a full structure of histohematological barriers in the organism.

The results of the studies on the determination of the optimal dose of the probiotic additive “Evitalia” (PAE) for the quails of the Texas breed have been presented in the article. The experiments were conducted on the quails aged 1–35 days. The object of the research was the probiotic additive “Evitalia” that consisted of eight components (the strains of lactic acidmicroorganisms, macro- and microelements). The subject of the investigation was the influence of PAE on the growth, preservation, the morphological composition and biochemical indices of blood. The studies were carried out in the following conditions of microclimate and sanitary regime: the air temperature in the pens-cages was 16–18 ºC in the autumn and winter period that was 5–7 ºC lower than it was provided by the standard; in spring the temperature was 23–15 ºС that was lower than it was provided by the standard (29–35 ºС). The concentration of carbon dioxide ranged within 0.20–0.25 % (2.0–2.5 l/m3), ammonia – 12–13.4 mg/m3, the general contamination of the air by microflora was 50–60 thousand KOE/m3. The experiments were conducted on the four groups of quails, 60 quails in each group. The quails of the control group were fed by water without PAE, the probiotic at the dose of 7 mg/500 ml of water was given to the quails of the experimental group 1 (E-1), 9 mg of probiotic/500 ml water received the birds of the experimental group 2 (E-2) and the quails of the experimental group 3 (E-3) were given the probiotic at the dose of 11 mg/500 ml water. The positive influence of the probiotic additive “Evitalia” on the growth and the body live weight gain of the quails was observedin the experimental groups as compared to the quails of the control group. The trustworthy increase in the growth and live weight gain of the quails was detected on the 7-, 14-, 21-, 35-day of their life (Р < 0.05), especially in the quails that received PAE at the dose of 9 mg (E-2). The quails of the experimental group 2 exceeded the others by the average daily live weight gains. The growth intensity of the quails in the experimental group 2 was 6.43 % higher than that of the control one, higher by 3.47 % and 5.57 % than in the experimental groups 1 and 3, respectively. The preservation of the quails in the control group was lower by 4.8 – 5.1 % as compared to the quails in the experimental groups. By the data on the growth of the body live weight, the composition and biochemical indices of blood of the quails it can be concluded that the optimal dose of the probioticadditive “Evitalia” is 9 mg/500 ml water that activates hematopoesis and stimulates the growth and development of quails.

The aim of the work was to study the influence of stimulant drugs – the regenerating biological stimulant (RBS) and Imunolac on the immunological state and productive qualities of piglets. RBS is a complex of organic compounds of animal tissue that stimulates nonspecific immunity and increases the protective functions of the body. Imunolac is a preparation of enzymatic hydrolysis of the cell wall of Lactobacillus, activating the cellular and humoral factors of non-specific animal resistance. To achieve this goal, the following tasks were set: to find out the microclimate condition and sanitary regime in the boxes in which the experimental animals were kept; – to study the influence of immunostimulating drugs on the growth and intensity of the test pigs, their safety; to study the dynamics of immunological parameters (circulating immune complex (CIC), T-and B-lymphocytes), the content of immunoglobulins (Jg G, Jg M and Jg A) while using RBS and Imunolac. The research was carried out in the pedigree plant «Stepnoy» of the Zaporozhye region on pigs of the Large white breed × Landras. Piglets of the control group were injected with 0.9% sodium chloride solution at a dose of 1 ml/head. During the experiment, the microclimate was monitored for temperature, relative humidity, air speed, carbon dioxide, ammonia, air contamination with microflora. Cellular indices were determined from the ratio of neutrophils to E. coli according to VG Gostivu, 1956, bactericidal activity of blood serum (BASK) – according to the method of O.V. Smirnova and TA. Kuzmenoy, 1966, lysozyme activity of blood serum (LASK) according to V. Dorofeychuk, 1968. The content of T lymphocytes was determined according to M. Jondal, 1973, B-lymphocytes – according to N.S. When piglets were grown at the temperature lower than 3,5–8 °C, humidity – by 5–8% higher, the parameters of NH3 and CO2 higher by 0.8–1.2%, the contamination microflora was twice as much as recommended by the sanitary norms the genetic productive potential of the animals is not fully realized, while – the highest daily average weight gain was in the pigs, which were injected intramuscularly with RBS growth stimulant. They exceeded the animals from the control group on the 20th and 30th days of the experiment – by 24.3% and 14.4%, live weight – by 15.3% (P < 0.05). The growth rate in the animals that were injected with imunolac was less expressed; the diseases with the symptoms of dyspepsia and bronchopneumonia were registered in 5–10% of the pigs from the experimental groups that received RBS and imunolac that is 10–12 times less as compared to the control group; in the pigs from the experimental group 1, the BASK was at the level of the average values of 56.52 ± 2.03%, from the experimental group 2 – 59.48 ± 1.80%, by 5.2% higher (P < 0.05); LASK indices in the animals of the experimental group tended to increase but the differences were not trustworthy (P < 0.5); the cell indices of resistance in the pigs that received RBS were higher: the phagocytic activity of blood serum – by 4.3% (P < 0.05), phagocytic number – by 9.7% (P <0.05); the highest concentration of immunoglobulin of class Jg G (21.82 ± 0.3 mg/ml) was revealed in the animals that received RBS preparations, the concentration of the above immunoglobulins was slightly below – 19.86 ± 0.18 mg/ml in the pigs that received imunolac (0–1). For immunoglobulins of class Jg M and Jg A, the fluctuations  between the experimental groups were within the limits of 2.23 ± 0.01 and 2.36 ± 0.09 mg/ml.

Data on the role of ensuring and maintaining comfortable hygienic parameters, sanitary regimes and technological methods aimed at realizing the genetic productive potential, reducing morbidity and safety, as well as increasing the resistance of the pig's organism under conditions of their intensive use in industrial complexes was summarized in this article. We emphasized that under the conditions of pig breeding, the genetic productive potential is practically realized only by 40 %, due to non-observance of the hygiene condition of keeping and technology of growing. We are talking about the genotypes of domestic breeding pigs, which are actively replaced by breeds of foreign companies, while, under equal conditions, they are not inferior to those imported from abroad, neither in terms of productive qualities, nor in terms of reproductive and adaptive abilities.It has been shown that the air temperature has the greatest effect on the animals' health among all abiotic factors, especially on sucker piglets, at a temperature of + 12 ° C and a humidity of 80% and above, as well as when the air is contaminated with microflora over 100 thousand CFU/m 3 we diagnosed hypoglycemia. In addition, pig breeding farms are unsafe in sanitary and environmental terms.Aerostases (stagnant zones) often registered in pigs ' farm, due to unregulated ventilation, 25-30 % in 2-row and up to 35-40 % in 4-row barn. The average daily gains decrease by 7-12 %, the milk production decreases by 10-13 % due to the lack of free access of pigs to water. Success in pig breeding is ensured by replacement young animals raised on their own farm, and not imported from other countries.Attention should be focused on prevention of early weaning of piglets (live weight not less than 7 kg at 24-28 days of age), regrouping, movement, which leads to the manifestation of stress, diarrhea, growth depression. Prevention of respiratory diseases is based on strict sanitation, adherence to the principle "everything is empty -everything is busy" and maintaining sanitary breaks. According to our research in a number of pig breeding farms more than 23% of sows are prematurely culled after 2-3 farrowings due to, infertility, limb diseases.