Objective – to study morphological features regenerative nerve neuroma after a complete intersection and restorative surgery with the use of electric welding technology.Materials and methods. The experimental model of operative intervention on injured peripheral nerve by immediate nerve stump’s epineurium welding and partial hindlimb immobilization was developed. The study was performed on 66 white, non-breeding male rats aged 5–7 months with a body weight of 350–450 g of vivarium breeding in Institute of Neurosurgery named after acad. A.P. Romodanov NAMS of Ukraine. Animals were divided into four experimental groups: 1 – surgical animals that included access to the sciatic nerve and its full intersection (n = 21), 2 – animals that were surgically intervened, which included access to the sciatic nerve, its intersection and the restoration of anatomical integrity by the application of an epineural suture (n = 18), 3 – animals that were operated surgically, which included access to the sciatic nerve, its intersection and the restoration of anatomical integrity by electric welding of the epineurium of the ends (n = 21), 4 – sham group, who were given access to the transverse nerve without its intersection (n = 6). In the experimental group of electric welding, the operation was performed using the apparatus EKWZ-300, «Patonmed» in the automatic mode dA2, with variable high-frequency (440 kHz) modulated current up to 0,3 A, the voltage at the 34 V pincer shield, the duration of the rectangular exposure pulse 0.8 s. Formated 5–6 electric weld point connections along the perimeter of the intersection with a complete alignment of the ends. The neurohistological method of study was used to study the morphological picture of the peripheral nerve in the region of the regenerative neurology and the distal segment in 1 and 3 months after surgical intervention. Results. It was established that simultaneous use of the technique of welded epineural joint of parts and partial immobilization of the limb in the postoperative period leads to uniform maturation of the neuro-connective tissue and its more complete neuroticisation.Conclusions. Recovery processes in the injured peripheral nerve occur better with the simultaneous formation of an immediate welded epineural joint of the ends and partial immobilization of the limb.

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В условиях экспериментальной дислипопротеидемии, которую моделировали путем скармливания кроликам холестерина в дозе 0,5 г / кг массы тела в течение 3 месяцев, с помощью морфометрических методов определяли особенности структурной перестройки коронарных артерий. Установили, что при экспериментальной дислипо-протеидемии отмечаются признаки выраженного ремоделирования артерий мелкого и среднего калибра, которые проявляются в виде утолщения их стенки и сужения просвета. Более выраженные морфологические изменения обнаружены в сосудах мелкого калибра. Так, площадь просвета артерий мелкого калибра уменьшилась на 48,67%, толщина стенки увеличилась на 42,38% по сравнению с группой интактных животных. Также статистически достоверно изменялись сосудистые индексы: индекс Вогенворта вырос в 4,24 раза, сосудистый индекс -в 2,11 раза, а индекс Керногана снизился в 4,02 раза. Указанные морфометрические изменения приводят к снижению функциональной способности сосудов, нарушению их пропускной способности и, как следствие, ухудшение кровоснабжения тканей миокарда с последующим развитием явлений гипоксии и ишемии.Ключевые слова: экспериментальная дислипопротеидемия, сердце, сосуды, морфометрия.The special features of structural transformation of coronary arteries were studied by morphometric methods under conditions of experimental dislipoproteinemia, provided by feeding model rabbits with cholesterol in a dose of 0.5 g/kg of body weight during 3 months. It was established, that the experimental dislipoproteinemia presented the signs of marked remodeling of small and medium arteries, manifested in the form of thickening the walls and narrowing the lumen. Small vessels presented the most pronounced morphological changes. Thus, the lumen of the small arteries decreased by 48.67%, while the wall thickness increased by 42.38% compared with the one in the group of intact animals. Vascular indices also demonstrated statistically significant changes: the Vogenvort index increased by a factor of 4.24, the vascular index -by a factor of 2.11, and the Kernogan index decreased 4.02 times. The above-mentioned morphometric changes lead to a decrease in the functional performance of vessels, a violation of their throughput and, as a consequence, a deterioration of blood supply to the myocardium tissues with subsequent development of hypoxia and ischemia.Key words: experimental dislipoproteinemia, hearth, vessels, morphometry. Стаття надійшла 27.07.2017 р.Рецензент Шепітько В.І. DEVELOPMENT OF WALKING TRACK DEVICE FOR FUNCTIONAL RECOVERY ANALYSIS AFTER EXPERIMENTAL SCIATIC NERVE INJURY e-mail: petrivtaras@gmail.comThe article is devoted to developing devise for Walking track test in rats after experimental sciatic nerve injury. Gradual gait improvement reflects the nerve function recovery in the temporal aspect. Its essence lies in getting rat footprints on paper, witch are analyzed. Then functional sciatic nerve index (SFI) is calculated using a special formula in experimental and intact limbs of the rats. The experiment was performed on outbre...

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